The majority of the Mycobacterium tuberculosis response to hypoxia and nitric oxide is through
the DosRS (DevRS) two-component regulatory system. The N-terminal input domain of …

PET radioligand binding to the 18-kD translocator protein (TSPO) in the brains of patients
with multiple sclerosis (MS) primarily reflects activated microglia and macrophages. We …

Inositol is utilized by Mycobacterium tuberculosis in the production of its major thiol and of
essential cell wall lipoglycans. We have constructed a mutant lacking the gene encoding …

The 106 small molecule metabolic (SMM) pathways in Escherichia coli are formed by the
protein products of 581 genes. We can define 722 domains, nearly all of which are …

Bacterial pathogens adapt to their host environments to a large extent through switching on
complex transcriptional programmes, and whole-genome microarray experiments promise to …

Small-molecule metabolism forms the core of the metabolic processes of all living organisms.
As early as 1945, possible mechanisms for the evolution of such a complex metabolic …

In this paper we survey a number of functional classification schemes applicable to genomes.
We present the concepts of depth, breadth and resolution as descriptors of the schemes' …

Escherichia coli has been a popular organism for studying metabolic pathways. In an attempt
to find out more about how these pathways are constructed, the enzymes were analysed …

We present a novel web-based resource, Gene3D , of precalculated structural assignments
to gene sequences and whole genomes. This resource assigns structural domains from the …

An important step in understanding the regulation of a prokaryotic genome is the generation
of its transcription unit map. The current strongest operon predictor depends on the …