TB affects around 10.6 million people each year and there are now around 155 million TB
survivors. TB and its treatments can lead to permanently impaired health and wellbeing. In …

The aim of this case series is to describe and evaluate our experience of continuous positive
airway pressure (CPAP) to treat type 1 respiratory failure in patients with COVID-19. CPAP …

Inhibitors of the bromodomain and extraterminal domain (BET) protein family attenuate the
proliferation of several tumor cell lines. These effects are mediated, at least in part, through …

Rationale: Noncommunicable respiratory diseases and exposure to air pollution are thought
to be important contributors to morbidity and mortality in sub-Saharan African adults. …

Purpose: Histone deacetylase inhibitors (HDACi) are epigenome-targeting small molecules
approved for the treatment of cutaneous T-cell lymphoma and multiple myeloma. They have …

Rationale Pulmonary tuberculosis (PTB) can cause post-TB lung disease (PTLD) associated
with respiratory symptoms, spirometric and radiological abnormalities. Understanding of the …

Histone deacetylase 3 (Hdac3) regulates the expression of lipid metabolism genes in
multiple tissues, however its role in regulating lipid metabolism in the intestinal epithelium is …

Background Non-communicable lung disease and exposure to air pollution are major
problems in sub-Saharan Africa. A high burden of chronic respiratory symptoms, spirometric …

Colorectal cancers (CRCs) often display histological features indicative of aberrant
differentiation but the molecular underpinnings of this trait and whether it directly drives disease …

BACKGROUND: Access to affordable inhaled medicines for chronic respiratory diseases (CRDs)
is severely limited in low- and middle-income countries (LMICs), causing avoidable …