User profiles for Rebecca C Fitzgerald

Rebecca Fitzgerald

Professor of Cancer Prevention, Cambridge University
Verified email at cam.ac.uk
Cited by 28386

Early detection of cancer

…, C Dive, M Emberton, S Esener, RC Fitzgerald… - Science, 2022 - science.org
Survival improves when cancer is detected early. However, ~50% of cancers are at an advanced
stage when diagnosed. Early detection of cancer or precancerous change allows early …

British Society of Gastroenterology guidelines on the diagnosis and management of Barrett's oesophagus

RC Fitzgerald, M Di Pietro, K Ragunath, Y Ang… - Gut, 2014 - gut.bmj.com
These guidelines provide a practical and evidence-based resource for the management of
patients with Barrett's oesophagus and related early neoplasia. The Appraisal of Guidelines …

Somatic mutant clones colonize the human esophagus with age

…, K Murai, K Mahbubani, MR Stratton, RC Fitzgerald… - Science, 2018 - science.org
The extent to which cells in normal tissues accumulate mutations throughout life is poorly
understood. Some mutant cells expand into clones that can be detected by genome …

Oesophageal cancer

EC Smyth, J Lagergren, RC Fitzgerald… - Nature reviews Disease …, 2017 - nature.com
Oesophageal cancer is the sixth most common cause of cancer-related death worldwide
and is therefore a major global health challenge. The two major subtypes of oesophageal …

Hereditary diffuse gastric cancer: updated consensus guidelines for clinical management and directions for future research

RC Fitzgerald, R Hardwick, D Huntsman… - Journal of medical …, 2010 - jmg.bmj.com
25–30% of families fulfilling the criteria for hereditary diffuse gastric cancer have germline
mutations of the CDH1 (E-cadherin) gene. In light of new data and advancement of …

Hereditary diffuse gastric cancer: updated clinical guidelines with an emphasis on germline CDH1 mutation carriers

…, R Vehof, JH van Krieken, RC Fitzgerald - Journal of medical …, 2015 - jmg.bmj.com
Germline CDH1 mutations confer a high lifetime risk of developing diffuse gastric (DGC) and
lobular breast cancer (LBC). A multidisciplinary workshop was organised to discuss genetic …

The future of early cancer detection

RC Fitzgerald, AC Antoniou, L Fruk, N Rosenfeld - Nature medicine, 2022 - nature.com
A proactive approach to detecting cancer at an early stage can make treatments more effective,
with fewer side effects and improved long-term survival. However, as detection methods …

The landscape of somatic mutation in normal colorectal epithelial cells

…, L O'Neill, C Alder, J Wang, RC Fitzgerald… - Nature, 2019 - nature.com
The colorectal adenoma–carcinoma sequence has provided a paradigmatic framework for
understanding the successive somatic genetic changes and consequent clonal expansions …

Hereditary diffuse gastric cancer: updated clinical practice guidelines

…, JL Davis, M di Pietro, RC Fitzgerald… - The Lancet …, 2020 - thelancet.com
Hereditary diffuse gastric cancer (HDGC) is an autosomal dominant cancer syndrome that is
characterised by a high prevalence of diffuse gastric cancer and lobular breast cancer. It is …

The mutational landscape of human somatic and germline cells

…, I Martincorena, R Heer, PJ Campbell, RC Fitzgerald… - Nature, 2021 - nature.com
Over the course of an individual’s lifetime, normal human cells accumulate mutations 1 . Here
we compare the mutational landscape in 29 cell types from the soma and germline using …