Aim In 2005, the Japan Geriatrics Society published a list of potentially inappropriate
medication that was an extract from the “Guidelines for medical treatment and its safety in the …

… Hidetaka Ota, Masato Eto, Sumito Ogawa, Katsuya Iijima, Masahiro Akishita, and
Yasuyoshi Ouchi … Proc Natl Acad Sci USA, 2007; 104: 14855-14860 20) Ota H, Akishita M …

Background Estrogen has been reported to augment endothelium-dependent vasodilatation.
The role of endogenous ovarian hormones in modulating endothelium-dependent …

Background— Prostaglandins generated by cyclooxygenase (COX) have been implicated
in hyperglycemia-induced endothelial dysfunction. However, the role of individual COX …

Yeast Sir2 plays critical roles in gene silencing, stress resistance and longevity. Mammalian
Sirt1 NAD + -dependent protein deacetylase, the closest homolog of Sir2, regulates cell …

Background— Tissue factor plays a pivotal role in thrombus formation in acute coronary
syndromes. However, the regulatory mechanisms underlying tissue factor expression are poorly …

Objective: To investigate the predictors of falls, such as comorbidity and medication, in geriatric
outpatients in a longitudinal observational study. Methods: A total of 172 outpatients (45 …

Vascular calcification is clinically important in the development of cardiovascular disease. It
is reported that hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase inhibitors (…

Objective—Statins (3-hydroxy-3-methylglutaryl–coenzyme A reductase inhibitors) have
pleiotropic vascular protective effects besides cholesterol lowering. Recently, experimental and …

Objective— Cilostazol, a selective inhibitor of PDE3, has a protective effect on endothelium
after ischemic vascular damage, through production of nitric oxide (NO). The purpose of the …