Background: Previous meta-analyses described moderate to large benefits of chondroitin in
patients with osteoarthritis. However, recent large-scale trials did not find evidence of an …

Background Multimorbidity is a phenomenon with high burden and high prevalence in the
elderly. Our previous research has shown that multimorbidity can be divided into the …

Thus, the task of writing Guidelines or Expert Consensus Documents covers not only the
integration of the most recent research, but also the creation of educational tools and …

We identified rare coding variants associated with Alzheimer's disease in a three-stage case–control
study of 85,133 subjects. In stage 1, we genotyped 34,174 samples using a whole-…

Markov (state) models (MSMs) and related models of molecular kinetics have recently received
a surge of interest as they can systematically reconcile simulation data from either a few …

Objective To compare the risk of developing Alzheimer’s disease (AD) dementia in late mild
cognitive impairment (LMCI), early MCI (EMCI), and subjective memory impairment (SMI) …

Although severe thunderstorms are one of the primary causes of catastrophic loss in the United
States, their response to elevated greenhouse forcing has remained a prominent source …

Multimorbidity is a health issue mostly dealt with in primary care practice. As a result of their
generalist and patient-centered approach, long-lasting relationships with patients, and …

Drugs that modify the risk of dementia in the elderly are of potential interest for dementia
prevention. Proton pump inhibitors (PPIs) are widely used to reduce gastric acid production, but …

Given the severe impacts of extreme heat on natural and human systems, we attempt to quantify
the likelihood that rising greenhouse gas concentrations will result in a new, permanent …