We have determined the in vitro and in vivo cellular distribution of the antineoplastic agent
paclitaxel (Taxol) in human blood and the influence of Cremophor EL (CrEL), the vehicle used …

We studied the effect of the Liverpool Care Pathway (LCP) on the documentation of care,
symptom burden and communication in three health care settings. Between November 2003 …

Objective To examine health professionals’ experiences of and attitudes towards the provision
of chemotherapy to patients with end stage cancer. Design Purposive, qualitative design …

Palliative sedation is undergoing extensive debate. The aims of this study were to describe
the practice of palliative sedation at a specialized acute palliative care unit and to study …

Background Clinical nursing practice may involve moral distress, which has been reported to
occur frequently when nurses care for dying patients. Palliative sedation is a practice that is …

Palliative care in The Netherlands is mainly provided by generalist professionals who are
part of the regular health care system. In order to provide good quality palliative care, they …

Purpose The purpose of this research is to study to what extent dying patients are aware of
the imminence of death, whether such awareness is associated with patient characteristics, …

Purpose Despite advances in cancer treatment, patients still die with unnecessary suffering.
Therefore, high-quality end-of-life care is needed. Variations in medication use at the end of …

The non-ionic surfactants Cremophor EL (CrEL) and Tween 80,both used as formulation
vehicles of many (anticancer) agentsincluding paclitaxel and docetaxel, are not …

Background The benefits and burdens of artificial nutrition (AN) and artificial hydration (AH)
in end-of-life care are unclear. We carried out a literature review on the use of AN and AH in …