Background Two-thirds of all patients search the internet prior to a health consultation. Aim
To explore how searching for online health information before visiting a doctor influences …

… 44 Thomas C, Auwerx J, Schoonjans K: Bile acids and the membrane bile acid receptor
TGR5 – connecting nutrition and metabolism. Thyroid 2008; 18: 167–174. 45 Katsuma S, …

Sirtuins (Sirt1–Sirt7) comprise a family of nicotinamide adenine dinucleotide (NAD + )-dependent
enzymes. While deacetylation reflects their main task, some of them have deacylase, …

Adipocyte differentiation is coordinatedly regulated by several transription factors. C/EBPβ,
C/EBPδ and ADD-1/SREBP-1 are active early during the differentiation process and induce …

… (K) NR increased the running distance and time during an endurance treadmill test in mdx
mice (mdx, n = 9; mdx NR, n = 12). (L and M) Hematoxylin and eosin (H&E) and Masson’s …

… (K and L) Plasma levels of liver enzymes (K) and lipids (L) at the end of the dietary intervention
(n = 8). The data are represented as the mean ± SE. Student’s unpaired t test; *p < 0.05, …

… In conclusion, we demonstrate that SIRT7 interacts with, deacetylates, and stabilizes the K-Cl
cotransporter KCC4 and … We thank the members of the Auwerx laboratory for discussion. …

With no approved pharmacological treatment, nonalcoholic fatty liver disease (NAFLD) is
now the most common cause of chronic liver disease in Western countries and its worldwide …

TGR5, a metabotropic receptor that is G-protein-coupled to the induction of adenylate cyclase,
has been recognized as the molecular link connecting bile acids to the control of energy …

In the framework of the design and development of TGR5 agonists, we reported that the
introduction of a C 23 (S)-methyl group in the side chain of bile acids such as chenodeoxycholic …