Objective To compare the efficacy, safety, and cost effectiveness of direct acting oral
anticoagulants (DOACs) for patients with atrial fibrillation. Design Systematic review, network meta-…

BACKGROUND: Warfarin is effective for stroke prevention in atrial fibrillation (AF), but
anticoagulation is underused in clinical care. The risk of venous thromboembolic disease during …

BACKGROUND: Atrial fibrillation (AF) is a common cardiac arrhythmia that increases the risk
of thromboembolic events. Anticoagulation therapy to prevent AF-related stroke has been …

Objective To compare the survival of different implant combinations for primary total hip
replacement (THR). Design Systematic review and network meta-analysis. Data sources Medline…

Background Ocrelizumab was approved for the treatment of relapsing multiple sclerosis (RMS)
and primary progressive multiple sclerosis (PPMS) by the US Food and Drug …

Psoriasis Area and Severity Index (PASI) 75 response is currently considered the gold
standard for assessing treatment efficacy in moderate‐to‐severe psoriatic patients. PASI 90 …

Background Although bariatric surgery is well established as an effective treatment for patients
with obesity and type 2 diabetes mellitus (T2DM), there exists reluctance to increase its …

Objectives To compare outcomes and cost-effectiveness of various initial imaging strategies
in the management of stable chest pain in a long-term prospective randomised trial. Setting …

Economic models are used in health technology assessments (HTAs) to evaluate the cost-effectiveness
of competing medical technologies and inform the efficient use of healthcare …

Introduction Secukinumab and adalimumab are approved for adults with active psoriatic
arthritis (PsA). In the absence of direct randomized controlled trial (RCT) data, matching-…