The causes of antibiotic resistance are complex and include human behaviour at many
levels of society; the consequences affect everybody in the world. Similarities with climate …

Background The ongoing outbreak of the recently emerged novel coronavirus (2019-nCoV)
poses a challenge for public health laboratories as virus isolates are unavailable while there …

Background Resistance to antibiotics is a major public-health problem and antibiotic use is
being increasingly recognised as the main selective pressure driving this resistance. Our aim …

A key unsolved question in the current coronavirus disease 2019 (COVID-19) pandemic is
the duration of acquired immunity. Insights from infections with the four seasonal human …

The methodology for EPOS2012 has been the same as for the other two productions. Leaders
in the field were invited to critically appraise the literature and write a report on a subject …

Background The spread of antibiotic-resistant bacteria poses a substantial threat to morbidity
and mortality worldwide. Due to its large public health and societal implications, multidrug-…

Tracking antibiotic consumption patterns over time and across countries could inform policies
to optimize antibiotic prescribing and minimize antibiotic resistance, such as setting and …

Background The efficacy of interleukin-6 receptor antagonists in critically ill patients with
coronavirus disease 2019 (Covid-19) is unclear. Methods We evaluated tocilizumab and …

Importance Evidence regarding corticosteroid use for severe coronavirus disease 2019 (COVID-19)
is limited. Objective To determine whether hydrocortisone improves outcome for …

Importance Clinical trials assessing the efficacy of IL-6 antagonists in patients hospitalized
for COVID-19 have variously reported benefit, no effect, and harm. Objective To estimate the …