Description of macrophage activation is currently contentious and confusing. Like the biblical
Tower of Babel, macrophage activation encompasses a panoply of descriptors used in …

Although intermittent increases in inflammation are critical for survival during physical injury
and infection, recent research has revealed that certain social, environmental and lifestyle …

Cyclooxygenase (COX) has two isoforms. Generally, COX 1 is constitutively expressed in
most tissues, where it maintains physiological processes 1; inducible COX 2 is considered a …

A recent focus meeting on Controlling Acute Inflammation was held in London, April 27-28,
2006, organized by DW Gilroy and SD Brain for the British Pharmacology Society. We …

The pro-inflammatory signalling pathways and cellular mechanisms that initiate the inflammatory
response have become increasingly well characterized. However, little is known about …

Inflammation involves the sequential activation of signaling pathways leading to the production
of both pro- and anti-inflammatory mediators. Although much attention has focused on pro…

Abstract Treatment of inflammatory diseases today is largely based on interrupting the
synthesis or action of mediators that drive the host's response to injury. Non-steroidal anti-…

In humans, the monocyte pool comprises three subsets (classical, intermediate, and
nonclassical) that circulate in dynamic equilibrium. The kinetics underlying their generation, …

Inflammatory responses, like all biological cascades, are shaped by a delicate balance
between positive and negative feedback loops. It is now clear that in addition to positive and …

Dysregulated inflammation is a central pathological process in diverse disease states.
Traditionally, therapeutic approaches have sought to modulate the pro- or anti-inflammatory limbs …