Trait-associated genetic variants affect complex phenotypes primarily via regulatory mechanisms
on the transcriptome. To investigate the genetics of gene expression, we performed cis…

Importance The prevalence of cardiometabolic multimorbidity is increasing. Objective To
estimate reductions in life expectancy associated with cardiometabolic multimorbidity. Design, …

In 328 type 2 diabetic patients followed for 9.0 years (mean), we investigated whether endothelial
dysfunction and chronic inflammation (estimated from plasma markers) can explain the …

Background— Different definitions of the metabolic syndrome have been proposed. Their
value in a clinical setting to assess cardiovascular disease (CVD) risk is still unclear. We …

The endothelium is a complex organ with a multitude of properties essential for control of
vascular functions. Dysfunction of the vascular endothelium is regarded as an important factor …

Context The evidence that measurement of the common carotid intima-media thickness (CIMT)
improves the risk scores in prediction of the absolute risk of cardiovascular events is …

ContextPersons with impaired glucose tolerance (IGT) are known to have an elevated risk
of developing diabetes mellitus. Less is known about diabetes risk among persons with …

Objectives To study the effects of metformin on the incidence of vitamin B-12 deficiency (<150
pmol/l), low concentrations of vitamin B-12 (150-220 pmol/l), and folate and homocysteine …

Mild renal insufficiency is associated with increased cardiovascular mortality: The Hoorn
Study. Background Cardiovascular mortality is extremely high in end-stage renal disease. …

Obesity, the insulin resistance syndrome, and atherosclerosis are closely linked and may all
be determinants of an increased acute-phase response. In this study, we examined the …