Adults with relapsed B cell acute lymphoblastic leukemia (B-ALL) have a dismal prognosis.
Only those patients able to achieve a second remission with no minimal residual disease (…

We report the findings from the first 10 patients with chemotherapy-refractory chronic
lymphocytic leukemia (CLL) or relapsed B-cell acute lymphoblastic leukemia (ALL) we have …

THE SERIOUS HAZARDS of Transfusion (SHOT) scheme is a UK-wide, independent,
professionally led hemovigilance system focused on learning from adverse events. SHOT was …

Aim To provide reliable survival estimates for people with chronic heart failure and explain
variation in survival by key factors including age at diagnosis, left ventricular ejection fraction, …

Objectives To report reliable estimates of short term and long term survival rates for people
with a diagnosis of heart failure and to assess trends over time by year of diagnosis, hospital …

Background Epstein-Barr virus (EBV)-associated posttransplantation lymphoproliferative
disease (PTLD) is a common, often fatal, complication of bone-marrow and solidorgan …

On the basis of promising preclinical data demonstrating the eradication of systemic B-cell
malignancies by CD19-targeted T lymphocytes in vivo in severe combined immunodeficient-…

Following in vitro fertilization, the criteria commonly used to select human embryos for transfer
are the cleavage rate and gross morphology, the contention being that those embryos …

Purpose: Passive immunotherapy with antitumor antibodies has the potential to induce
active tumor immunity via the opsonic enhancement of immunogenicity of tumor antigen. We …

Background Anterior cruciate ligament (ACL) rupture is a common debilitating injury that
can cause instability of the knee. We aimed to investigate the best management strategy …