[HTML][HTML] Proteolytic origin of the soluble human IL-6R in vivo and a decisive role of N-glycosylation
…, JC Ehlers, CW Hung, CM Flynn… - PLoS …, 2017 - journals.plos.org
Signaling of the cytokine interleukin-6 (IL-6) via its soluble IL-6 receptor (sIL-6R) is responsible
for the proinflammatory properties of IL-6 and constitutes an attractive therapeutic target, …
for the proinflammatory properties of IL-6 and constitutes an attractive therapeutic target, …
[HTML][HTML] Control of ADAM17 activity by regulation of its cellular localisation
I Lorenzen, J Lokau, Y Korpys, M Oldefest, CM Flynn… - Scientific reports, 2016 - nature.com
An important, irreversible step in many signalling pathways is the shedding of membrane-anchored
proteins. A Disintegrin And Metalloproteinase (ADAM) 17 is one of the major …
proteins. A Disintegrin And Metalloproteinase (ADAM) 17 is one of the major …
[HTML][HTML] Activation of Toll-like Receptor 2 (TLR2) induces Interleukin-6 trans-signaling
Signaling of the pleiotropic cytokine Interleukin-6 (IL-6) via its soluble IL-6R (sIL-6R) has
been termed trans-signaling and is thought to be responsible for the pro-inflammatory …
been termed trans-signaling and is thought to be responsible for the pro-inflammatory …
[HTML][HTML] Proteolytic control of Interleukin-11 and Interleukin-6 biology
Interleukin-11 (IL-11) and IL-6 are secreted glycoproteins which fulfill important homeostatic
functions. Activation of target cells occurs via membrane-bound IL-11 and IL-6 receptors (IL-…
functions. Activation of target cells occurs via membrane-bound IL-11 and IL-6 receptors (IL-…
[HTML][HTML] The IL-6-neutralizing sIL-6R-sgp130 buffer system is disturbed in patients with type 2 diabetes
…, Y Garbers, CM Flynn… - American Journal …, 2019 - journals.physiology.org
Serum levels of interleukin-6 (IL-6) are increased in patients with type 2 diabetes (T2D). IL-6
exerts its pleiotropic effects via the IL-6 α-receptor (IL-6R), which exists in membrane-bound …
exerts its pleiotropic effects via the IL-6 α-receptor (IL-6R), which exists in membrane-bound …
[PDF][PDF] Mutations in craniosynostosis patients cause defective interleukin-11 receptor maturation and drive craniosynostosis-like disease in mice
Premature closure of the sutures that connect the cranial bones during development of the
mammalian skull results in a phenotype called craniosynostosis. Recently, several …
mammalian skull results in a phenotype called craniosynostosis. Recently, several …
[HTML][HTML] Cathepsin S provokes interleukin-6 (IL-6) trans-signaling through cleavage of the IL-6 receptor in vitro
CM Flynn, Y Garbers, S Düsterhöft, R Wichert… - Scientific reports, 2020 - nature.com
The cytokine interleukin-6 (IL-6) fulfills its pleiotropic functions via different modes of signaling.
Regenerative and anti-inflammatory activities are mediated via classic signaling, in which …
Regenerative and anti-inflammatory activities are mediated via classic signaling, in which …
Delivering routine immunisations in London during the COVID-19 pandemic: lessons for future vaccine delivery. A mixed-methods study
H Skirrow, C Flynn, A Heller, C Heffernan… - BJGP open, 2021 - bjgpopen.org
Background General practices in England have continued to care for patients throughout the
COVID-19 pandemic by instigating major changes to service delivery. Immunisations have …
COVID-19 pandemic by instigating major changes to service delivery. Immunisations have …
[HTML][HTML] Interleukin-6 controls recycling and degradation, but not internalization of its receptors
CM Flynn, B Kespohl, T Daunke, Y Garbers… - Journal of Biological …, 2021 - ASBMB
Interleukin-6 (IL-6) is a cytokine implicated in proinflammatory as well as regenerative
processes and acts via receptor complexes consisting of the ubiquitously expressed, signal-…
processes and acts via receptor complexes consisting of the ubiquitously expressed, signal-…
Cleavage of the Interleukin-11 receptor induces processing of its C-terminal fragments by the gamma-secretase and the proteasome
The cytokine Interleukin-11 (IL-11) signals through the membrane-bound IL-11 receptor (IL-11R),
which is expressed in a cell-type specific manner. We have recently shown that the …
which is expressed in a cell-type specific manner. We have recently shown that the …