User profiles for Alex Mackay

Alex MacKay

- Verified email at physics.ubc.ca - Cited by 17514

Alex Mackay

- Verified email at uow.edu.au - Cited by 3225

In vivo visualization of myelin water in brain by magnetic resonance

A Mackay, K Whittall, J Adler, D Li… - Magnetic resonance …, 1994 - Wiley Online Library
We exploit the intrinsic difference in magnetic resonance spin‐spin relaxation time, T 2 ,
between water associated with myelin sheaths and water in other central nervous system tissue …

In vivo measurement of T2 distributions and water contents in normal human brain

KP Whittall, AL Mackay, DA Graeb… - Magnetic resonance …, 1997 - Wiley Online Library
Using a 32‐echo imaging pulse sequence, T 2 relaxation decay curves were acquired from
five white‐ and six gray‐matter brain structures outlined in 12 normal volunteers. The water …

[HTML][HTML] Rare variant contribution to human disease in 281,104 UK Biobank exomes

…, I Tachmazidou, D Vitsios, SVV Deevi, A Mackay… - Nature, 2021 - nature.com
Genome-wide association studies have uncovered thousands of common variants associated
with human disease, but the contribution of rare variants to common disease remains …

Ages for the Middle Stone Age of southern Africa: implications for human behavior and dispersal

…, RF Galbraith, HJ Deacon, R Grun, A Mackay… - Science, 2008 - science.org
The expansion of modern human populations in Africa 80,000 to 60,000 years ago and their
initial exodus out of Africa have been tentatively linked to two phases of technological and …

Myelin water imaging of multiple sclerosis at 7 T: correlations with histopathology

C Laule, P Kozlowski, E Leung, DKB Li, AL MacKay… - Neuroimage, 2008 - Elsevier
Myelin water imaging (MWI) promises to be invaluable in understanding neurological
diseases like MS. However, a limitation of MWI is signal to noise ratio. Recently, a number of …

[HTML][HTML] Magnetic resonance imaging of myelin

…, DKB Li, TL Traboulsee, GRW Moore, AL MacKay - …, 2007 - Elsevier
The ability to measure myelin in vivo has great consequences for furthering our knowledge
of normal development, as well as for understanding a wide range of neurological disorders. …

Insights into brain microstructure from the T2 distribution

A MacKay, C Laule, I Vavasour, T Bjarnason… - Magnetic resonance …, 2006 - Elsevier
T 2 weighting is particularly sensitive, but notoriously unspecific, to a wide range of brain
pathologies. However, careful measurement and analysis of the T 2 decay curve from brain …

Ion transport in halophytes

S Shabala, A Mackay - Advances in botanical research, 2011 - Elsevier
The increasing problem of global land salinisation and associated multibillion dollar losses
in crop production require a better understanding of key physiological mechanisms …

Applications of stimulated echo correction to multicomponent T2 analysis

…, B Mädler, QS Xiang, A MacKay… - Magnetic resonance …, 2012 - Wiley Online Library
We propose a multicomponent fitting algorithm for multiecho T 2 data which allows for
correction of T 2 distributions in the presence of stimulated echoes. Tracking the population of …

Rapid whole cerebrum myelin water imaging using a 3D GRASE sequence

T Prasloski, A Rauscher, AL MacKay, M Hodgson… - Neuroimage, 2012 - Elsevier
Myelin water imaging, a magnetic resonance imaging technique capable of resolving the
fraction of water molecules which are located between the layers of myelin, is a valuable tool …