Abstract
We have studied the effects of long-term tetracycline and erythromycin administration on the fecal flora of patients and their relatives. Tetracycline administration selects for multiply antibiotic-resistant organisms in both patients and relatives. Erythromycin exerts no such selection pressure. The mechanisms by which this may occur are discussed.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Acne Vulgaris / drug therapy*
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Adolescent
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Adult
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Drug Resistance, Microbial
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Erythromycin / therapeutic use*
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Escherichia coli / drug effects*
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Escherichia coli / isolation & purification
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Feces / microbiology
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Female
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Humans
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Intestines / microbiology*
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Male
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Tetracycline / therapeutic use*
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Time Factors
Substances
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Erythromycin
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Tetracycline