One of the many problems in providing anaesthesia for morbidly obese patients is the influence of obesity on pharmacokinetics and pharmacodynamics. Drug administration in obese patients is difficult because recommended doses are based on pharmacokinetic data obtained from individuals with normal weights; therefore, mistakes in the determination of the appropriate dose are often made. Because of comorbidity in these patients, the function of organs involved in drug elimination (e.g. kidney, liver) can be affected making pharmacokinetics more difficult and complex.
