Systematic ReviewNitrofurantoin vs other prophylactic agents in reducing recurrent urinary tract infections in adult women: a systematic review and meta-analysis
Section snippets
Materials and Methods
A detailed description of the methods is available online in a protocol registered a priori with the PROSPERO registry (www.crd.york.ac.uk/PROSPERO; record number 23966). An investigational review board reviewed and exempted this study.
Description of included studies
The literature search yielded 1061 articles, of which 78 were reviewed in full text (Figure 1). Of these studies, 12 randomized control trials met the inclusion criteria. These trials included a total of 1063 patients, in whom 344 bacterial urinary tract infections were reported from 10 studies. The remaining studies reviewed in full text were excluded for the following reasons: studies without nitrofurantoin prophylaxis therapy, nitrofurantoin therapy with acute bacterial infections, other
Comment
Twelve randomized, clinical trials involving 1063 patients were included in this review. No significant differences in prophylactic antibiotic treatment with nitrofurantoin, norfloxacin, trimethoprim, sulfamethoxazole/trimethoprim, methenamine hippurate, or cefaclor were found in clinical or microbiological cure in adult nonpregnant women with recurrent urinary tract infections (9 randomized control trials, 673 patients, relative risk ratio, 1.06, 95% confidence interval, 0.89–1.27, I2, 65%,
References (38)
- et al.
Urinary tract infection: self-reported incidence and associated costs
Ann Epidemiol
(2000) - et al.
Prevention of recurrent urinary tract infections in women: antimicrobial and nonantimicrobial strategies
Infect Dis Clin North Am
(2014) Recurrent urinary tract infection in women
Int J Antimicrob Agents
(2001)- et al.
Antibiotic resistance in Escherichia coli outpatient urinary isolates: final results from the North American Urinary Tract Infection Collaborative Alliance (NAUTICA)
Int J Antimicrob Agents
(2006) - et al.
Regular monitoring of older women on long-term nitrofurantoin prophylaxis—what does it mean practically?
Urol Pract
(2016) - et al.
Prevention of recurrent urinary infections in women: a comparative trial between nitrofurantoin and methenamine hippurate
J Urol
(1981) The epidemiology of urinary tract infection
Nat Rev Urol
(2010)- et al.
National Center for Health Statistics (US). Ambulatory medical care utilization estimates for 2006
Natl Health Stat Report
(2008) - et al.
Guidelines on uncomplicated urinary tract infections are difficult to follow: perceived barriers and suggested interventions
BMC Fam Pract
(2010) - et al.
Guidelines for antimicrobial treatment of uncomplicated acute bacterial cystitis and acute pyelonephritis in women. Infectious Diseases Society of America (IDSA)
Clin Infect Dis
(1999)
Acute uncomplicated cystitis in an era of increasing antibiotic resistance: a proposed approach to empirical therapy
Clin Infect Dis
Urinary tract infections in females
Clin Infect Dis
Management of urinary tract infections in adults
N Engl J Med
Recurrence of urinary tract infection in a primary care setting: analysis of a 1-year follow-up of 179 women
Clin Infect Dis
Recurrent cystitis in non-pregnant women
Clin Evid (Online)
Treatment of urinary tract infections in nonpregnant women. ACOG Practice bulletin no. 91
Obstet Gynecol
Antibiotic resistance—problems, progress, and prospects
N Engl J Med
Nitrofurantoin: the return of an old friend in the wake of growing resistance
BJU Int
Methods for the drug effectiveness review project
BMC Med Res Methodol
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The authors report no conflict of interest.