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Genotoxic effect of Goeckerman regimen of psoriasis

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Abstract

Goeckerman regimen (GR) of psoriasis includes daily dermal application of crude coal tar (CCT) and dermal exposure to UV-A and UV-B radiation. Observed group consisted of 23 patients with psoriasis treated by GR. Therapeutic ointment contained 5% of CCT. The level of psoriasis area and severity index was significantly decreased after GR (P < 0.001) and confirms high efficiency of GR. High levels of selected metabolites of pyrene and phenanthrene indicated high level of dermal penetration. We found significantly increased urinary mutagenicity in samples collected in the middle and in the end of GR (TA98+S9, P < 0.01; YG1041-S9, P < 0.001; YG1041+S9, P < 0.001). Significant increasing of chromosomal aberrations in peripheral lymphocytes (CA) in blood samples collected in the end of GR (P < 0.001) and consecutive decreasing of CA in 78th day after the end of GR has been observed. Almost all results indicated that the patients could be endangered by a peak genotoxic exposure. Nevertheless, the genotoxic effect does not seem to be long lasting. Despite conflicting results from cancer epidemiological studies, it is evident that single GR can contribute to the total load of environmental mutagens in a group of treated patients.

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Acknowledgments

The work is supported by the Research project IGA No. NR 8154-3 and by the Research project No. 00179906, Ministry of Health, Czech Republic. The authors acknowledge the language assistance of Ms. Isobel Black and Ms. Dana Fialova.

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Authors and Affiliations

  1. Faculty of Medicine in Hradec Kralove, Institute of Hygiene and Preventive Medicine, Charles University in Prague, Simkova 870, 500 38, Hradec Kralove, Czech Republic

    Zdenek Fiala & Jindra Smejkalova

  2. Faculty of Medicine in Hradec Kralove, Institute of Pathological Physiology, Charles University in Prague, Simkova 870, 500 38, Hradec Kralove, Czech Republic

    Lenka Borska & Jan Kremlacek

  3. National Institute of Health, Srobarova 48, 100 42, Praha 10, Czech Republic

    Anna Pastorkova & Milena Cerna

  4. Clinic of Dermal and Venereal Diseases, University Hospital, Sokolska 581, 500 05, Hradec Kralove, Czech Republic

    Kvetoslava Hamakova

Authors
  1. Zdenek Fiala
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  2. Lenka Borska
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  3. Anna Pastorkova
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  4. Jan Kremlacek
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  5. Milena Cerna
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  6. Jindra Smejkalova
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  7. Kvetoslava Hamakova
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Correspondence to Zdenek Fiala or Lenka Borska.

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Fiala, Z., Borska, L., Pastorkova, A. et al. Genotoxic effect of Goeckerman regimen of psoriasis. Arch Dermatol Res 298, 243–251 (2006). https://doi.org/10.1007/s00403-006-0691-z

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  • DOI: https://doi.org/10.1007/s00403-006-0691-z

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