| Parameter | Type | Mean cost, £ | Source |
|---|---|---|---|
| Fosfomycin 3 g once | Prescription | 4.86 | Profile Pharmaa |
| Nitrofurantoin 50 mg four times a day for 7 days | Prescription | 13.93 | BNF 27 |
| Nitrofurantoin (MR) 100 mg twice daily for 7 days | Prescription | 9.50 | |
| Nitrofurantoin 100 mg four times a day for 3 days | Prescription | 8.14 | |
| Pivmecillinam 200 mg three times a day for 7 days | Prescription | 9.45 | |
| Pivmecillinam 400 mg twice daily for 3 days | Prescription | 5.40 | |
| Pivmecillinam, 200 mg twice daily for 7 days | Prescription | 6.30 | |
| Trimethoprim 200 mg twice daily for 7 days | Prescription | 1.00 | |
| Trimethoprim 200 mg once | Prescription | 0.07 | |
| Pyelonephritis | Hospitalisation | 3992.00 | National schedule of reference costs26 |
| Pyelonephritis | Outpatient visit | 94.00 | |
| Urine analysis | Test | 7.00 | |
| GP appointment | Per patient contact (11.7 minutes) | 46.00 | PSSRU24 |
| Dipstick test | Test | 0.40 | Little et al 25 |
| Pathway | |||
| Risk of pyelonephritis if clinical cure not achieved, % | 4.00 | McKinnel et al 9 | |
| Risk of hospitalisation if pyelonephritis, % | 20.00 | ||
aThis price was provided by Profile Pharma, which is the approved UK distributor of Monuril (fosfomycin trometamol) on behalf of the marketing authorisation holder Zambon. Monuril was launched onto the UK market at this price in August 2016. BNF = British National Formulary. MR = modified release. PSSRU = Personal Social Services Research Unit.