| Results of NMA of 11 RCTs | Model parameters derived from NMA using McNulty et al 22 | Resistance rate from ECO-SENS II, 23 % | ||||
|---|---|---|---|---|---|---|
| Odds ratio | 95% CI | Posterior mean cure rate, % | Resistant cure rate, % | Sensitive cure rate, % | ||
| Fosfomycin 3 g once | 1 | – | 84.2 | 53.1 | 84.3 | 0.5 |
| Nitrofurantoin 50 mg four times a day for 7 days | 0.82 | 0.30 to 2.18 | 79.9 | 50.3 | 79.9 | 0.0 |
| Nitrofurantoin (MR) 100 mg twice daily for 7 days | 1.15 | 0.55 to 2.56 | 85.0 | 53.6 | 85.0 | 0.0 |
| Nitrofurantoin 100 mg four times a day for 3 days | 0.34 | 0.06 to 2.05 | 62.4 | 39.3 | 62.4 | 0.0 |
| Pivmecillinam 200 mg three times a day for 7 days | 0.63 | 0.16 to 2.57 | 75.0 | 47.4 | 75.3 | 1.0 |
| Pivmecillinam 400 mg twice daily for 3 days | 0.47 | 0.14 to 1.57 | 69.8 | 44.2 | 70.1 | 1.0 |
| Pivmecillinam 200 mg twice daily for 7 days | 0.69 | 0.17 to 2.78 | 76.2 | 48.2 | 76.5 | 1.0 |
| Trimethoprim 200 mg twice daily for 7 days | 1.29 | 0.43 to 4.02 | 85.9 | 57.3 | 90.8 | 14.9 |
| Trimethoprim 200 mg once | 0.31 | 0.06 to 1.38 | 61.1 | 40.8 | 64.7 | 14.9 |
None of the treatment effects were statistically significantly different at a conventional 5% level, and pairwise comparisons indicated that no one treatment was significantly more effective than any other. CI = credible interval. MR = modified release. NMA = network meta analyses. RCT = randomised controlled trial.