| Diagnosis | Influenza | SARS-CoV-2 | |||||
|---|---|---|---|---|---|---|---|
| Year or season | 2017 | 2018 | 2019 | 2020 | First wave | Second wave | |
| Population sizea | 254 586 | 276 275 | 288 703 | 288 305 | 288 305 | 288 305 | |
| Number of patients | 4579 | 8016 | 4354 | 1422 | 1702 | 6904 | |
| Age range in years (mean) | 18–100 (51) | 18–102 (51) | 18–101 (51) | 18–99 (48) | 18–100 (50) | 18–100 (48) | |
| Confirmed COVID-19 (n) | – | – | – | – | 247 | 5682 | |
| Suspected COVID-19 (n) | – | – | – | – | 1455 | 1222 | |
| Number of contacts with GP practices | 4858 | 9298 | 4922 | 1542 | 2165 | 8867 | |
| Risk factors for adverse course of COVID-1 | |||||||
| Age ≥70 year % (n) | 18.8 (860) | 18.2 (1457) | 18.5 (804) | 13.3 (189) | 14.9 (253) | 11.7 (806) | |
| Male % (n) | 35.4 (1622) | 36.5 (2929) | 34.6 (1507) | 37.7 (536) | 38.4 (653) | 42.3 (2923) | |
| Obesity, BMI >29% (n)b | 17.6 (807) | 18.2 (1456) | 18.9 (823) | 17.2 (245) | 6.6 (113) | 16.6 (1147) | |
| Smoking: current and previous % (n)c | 25.9 (1185) | 25.9 (2077) | 25.2 (1099) | 23.1 (329) | 9.8 (166) | 19.3 (1330) | |
| Heart disease % (n)d | 12.3 (565) | 10.5 (844) | 10.4 (452) | 7.2 (102) | 3.5 (59) | 8.0 (550) | |
| Diabetes mellitus % (n)e | 10.4 (477) | 10.5 (839) | 9.8 (427) | 8.2 (116) | 10.6 (181) | 9.9 (682) | |
| Severe chronic respiratory disease (n)f | 3.4 (154) | 3.5 (277) | 3.4 (150) | 2.8 (40) | 6.2 (105) | 2.9 (198) | |
| HIV infection % (n)g | 0.3 (13) | 0.3 (21) | 0.3 (15) | 0.1 (1) | 0.4 (6) | 0.3 (20) | |
| Severe kidney disease (eGFR <26) % (n)h | 0.4 (19) | 0.4 (35) | 0.2 (9) | 0.2 (3) | 0.6 (11) | 0.3 (21) | |
| Liver failure % (n)i | 0.1 (1) | 0 | 0.1 (1) | 0 | 0 | 0 | |
| Down's syndrome % (n) | 0.1 (1) | 0.1 (1) | 0.1 (3) | 0 | 0 | 0.1 (1) | |
a In total, 348 553 individual patients were registered during the study period 2016–2020 in the ELAN Datawarehouse. The population size per year is the number of patients registered during that study year. bMissing BMI (year or season, n): 2017, 2507; 2018, 4338; 2019, 2378; 2020, 847; first wave, 1434; second wave, 4274. cMissing smoke status (year or season, n): 2017, 2403; 2018, 4201; 2019, 2312; 2020, 805; first wave, 1404; second wave, 4182. dHeart disease: ICPC K74 Angina pectoris, ICPC K75 and K76 Myocardial infarction, ICPC K77 Heart failure, ICPC K78 Atrial fibrillation.eDiabetes mellitus: ICPC T90 Diabetes mellitus. fSevere chronic respiratory disease: ICPC R91 Chronic bronchitis, ICPC R89 Congenital anomaly respirator, ICPC R91 Bronchiectasis, ICPC R95 COPD.gHIV infection: ICPC B90 Use of antiviral medication for an HIV infection.hSevere renal disease: ICPC U99 (.01) Renal impairment and eGFR <25 ml/min/1.73 m2. ILiver failure: ICPC D97 Cirrhosis, Liver failure of liver decompensation, Contraindication label liver impairment.
BMI = body mass index. ICPC = International Classification of Primary Care codes first edition. SARS-CoV-2 = severe acute respiratory syndrome coronavirus 2.