Table 2. Significant abnormality, defined as polyps, inflammation, or cancer, identified by the primary care physician at the time of the LumenEye examination (N = 110 patients), compared with the findings of follow-up investigation or expert review, and sensitivity, specificity, positive predictive value, and negative predictive value of the LumenEye in the identification of pathology compared with subsequent colonoscopy, flexible sigmoidoscopy, or CTVC findings

Pathology recorded, n		Cancer	Polyp	Inflammation
Identified in primary care		2	6	16
Identified after formal investigation or expert review of recorded images		2	11	15
All patients	Any pathology	Cancer	Polyp	Inflammation
TP, n	9	2	5	4
TN, n	32	46	45	41
FP, n	4	0	1	3
FN, n	1	0	1	0
Sensitivity = TP/TP + FN, %	90.0	100	83.3	100
Specificity = TN/TN + FP, %	88.9	100	97.8	93.2
PPV = TP/(TP + FP), %	69.2	100	83.3	57.1
NPV = TN/(TN + FN), %	97.0	100	97.8	100
Patients presenting with rectal bleeding ( n = 28)	Any pathology	Cancer	Polyp	Inflammation
TP, n	8	2	3	4
TN, n	15	25	24	21
FP, n	4	0	1	3
FN, n	1	0	1	0
Sensitivity = TP/TP + FN, %	88.9	100	75.0	100
Specificity = TN/TN + FP, %	78.9	100	96.0	87.5
PPV = TP/TP + FP, %	66.7	100	75.0	57.1
NPV = TN/(TN + FN), %	93.8	100	96.0	100

CTVC = computed tomography virtual colonoscopy. FN = false negative. FP = false positive. NPV = negative predictive value. PPV = positive predictive value. TN = true negative. TP = true positive.