Table 1. Participant inclusion criteria: patients at increased risk of ADEs with NSAIDs or antiplatelet medication at baseline
Type of ADEAny of the following clinical criteria
Gastrointestinal bleedPrior peptic ulcer diagnosisa
Aged ≥75 years
Aged ≥65 years and prescribed aspirin
Prescribed oral anticoagulant
Renal impairmentPrescribed both renin-angiotensin system blocker and diuretic
Chronic kidney disease (eGFR<60 at the most recent test)
Cardiac failureHeart failure evera
  • Prescribed medication is defined as any prescription for this category of medication in the previous 14 weeks, as identified from the electronic prescribing database of the participating practices. This time period is used because in New Zealand most medication is prescribed for a maximum of 12 weeks.

  • aObtained general practice electronic disease coding from the participating practices.

  • ADE = adverse drug event. eGFR = estimated glomerular filtration rate. NSAID = non-steroidal anti-inflammatory drug.