Table 1. Participant inclusion criteria: patients at increased risk of ADEs with NSAIDs or antiplatelet medication at baseline

Type of ADE	Any of the following clinical criteria
Gastrointestinal bleed	Prior peptic ulcer diagnosis^a
	Aged ≥75 years
	Aged ≥65 years and prescribed aspirin
	Prescribed oral anticoagulant
Renal impairment	Prescribed both renin-angiotensin system blocker and diuretic
	Chronic kidney disease (eGFR<60 at the most recent test)
Cardiac failure	Heart failure ever^a

Prescribed medication is defined as any prescription for this category of medication in the previous 14 weeks, as identified from the electronic prescribing database of the participating practices. This time period is used because in New Zealand most medication is prescribed for a maximum of 12 weeks.
^aObtained general practice electronic disease coding from the participating practices.
ADE = adverse drug event. eGFR = estimated glomerular filtration rate. NSAID = non-steroidal anti-inflammatory drug.