Table 2. Diagnostic accuracy at each threshold of clinical prediction rule
Threshold n above / belowSensitivity(95% CI)Specificity(95% CI)ROC(95% CI)PPV(95% CI)NPV(95% CI)
Centor ≥1424/7890.1 (81.5 to 95)16.6 (13.2 to 20.5)0.53 (0.5 to 0.57)17.2 (13.7 to 21.2)89.7 (80.8 to 95.5)
Centor ≥2211/29861.7 (50.3 to 72.3)61.8 (56.9 to 66.4)0.62 (0.6 to 0.68)23.7 (18.1 to 30)89.3 (85.2 to 92.6)
Centor ≥374/42823.5 (14.8 to 34.2)86.9 (83.3 to 90)0.55 (0.50 to 0.60)25.7 (16.2 to 37.2)85.5 (81.8 to 88.7)
Centor ≥412/4903.7 (0.77 to 10.4)97.9 (96 to 99)0.51 (0.49 to 0.53)25 (5.49 to 57.2)84.1 (80.5 to 87.2)
FeverPAIN ≥1434/6893.8 (86.2 to 98)15 (11.7 to 18.7)0.54 (0.51 to 0.58)17.5 (14.1 to 21.4)92.6 (83.7 to 97.6)
FeverPAIN ≥2251/25163 (51.5 to 73.4)52.5 (47.6 to 57.4)0.58 (0.52 to 0.64)20.3 (15.5 to 25.8)88 (83.4 to 91.8)
FeverPAIN ≥393/40922.2 (13.7 to 32.8)82.2 (78.2 to 85.7)0.52 (0.48 to 0.57)19.4 (11.9 to 28.9)84.6 (80.7 to 88)
FeverPAIN ≥411/4913.7 (0.77 to 10.4)98.1 (96.3 to 99.2)0.51 (0.49 to 0.53)27.3 (6.02 to 61)84.1 (80.6 to 87.2)
FeverPAIN ≥52/5001.29 (0.031 to 6.69)99.8 (98.7 to 100)0.51 (0.49 to 0.52)50 (1.26 to 98.7)84 (80.5 to 87.1)
  • ROC = area under receiver operating characteristics curve. PPV = positive predictive value. NPV = negative predictive value