| High LDL-C population (LDL-C ≥5.0 mmol/l), n % | High LDL-C without potential secondary cause (subgroup), n % | |
|---|---|---|
| Cardiovascular profile | ||
| Total | 236 (100) | 115 (100) |
| Ischaemic heart disease | 41 (17.4) | 24 (20.9) |
| MI | 11 (26.8) | 8 (33.3) |
| AP | 22 (53.7) | 13 (54.2) |
| CHF | 8 (19.5) | 5 (20.8) |
| PCI | 12 (29.2) | 9 (37.5) |
| CABG | 4 (9.8) | 3 (12.5) |
| Cerebral vascular disease | 31 (13.1) | 13 (11.3) |
| Peripheral artery disease | 15 (6.4) | 7 (6.1) |
| Criteria for clinical FH (DLCN) | ||
| Past medical history | ||
| Premature ischaemic heart disease | 15 (6.4) | 8 (7.0) |
| Premature cerebrovascular disease | 7 (3.0) | 2 (1.7) |
| Premature peripheral artery disease | 4 (1.7) | 2 (1.7) |
| Clinical features | ||
| Tendon xanthomas | 0 (0.0) | 0 |
| Arcus cornealis | 1 (0.4) | 1 (0.9) |
| Family medical history | ||
| Family history of ischaemic heart disease | 51 (21.6) | 36 (31.3) |
| Family history of cerebral vascular disease | 13 (5.5) | 9 (7.8) |
| Family history of peripheral artery disease | 4 (1.7) | 2 (1.7) |
| Family history of hyperlipidaemia | 27 (11.4) | 17 (14.8) |
| No family history available | 84 (35.6) | 48 (41.7) |
| Result of screening | ||
| Definite FH – DLCN score >8 | 22 (9.3) | 15 (13.0) |
| Probable FH – DLCN score 6–7 | 12 (5.1) | 6 (5.2) |
| Possible FH – DLCN score 3–5 | 202 (85.6) | 94 (81.7) |
| Actual diagnostic yield | ||
| Confirmed diagnosis of FH | 3 (1.3) | 1 (0.9) |
| FH suspected by GP | 26 (11.0) | 22 (19.1) |
Subgroup has been derived from the high LDL-C population. Information has been obtained by reading the patient records for all the patients. AP = angina pectoris. CABG = coronary artery by-pass grafting. CHF = congestive heart failure. DLCN = Dutch Lipid Clinic Network. FH = familial hypercholesterolaemia. MI = myocardial infarction. PCI = percutaneous intervention.