Table 1. Number of recorded strokes and risk factor prevalence in the three cohorts identified in CPRD, HES, and ONS data (N = 72 298)
CharacteristicPrimary careCPRD,a n (%)Hospital admissions HES,b n (%)Cause-specific mortalityONS, n (%)
All strokes 54 929 (100)51 013 (100)17 977 (100
Ischaemic strokes17 027 (31.0)30 554 (59.9)2248 (12.5)
All haemorrhagic strokes SAH Other haemorrhagic strokec 9181 (16.7)2749 (5.0)6432 (11.7)11 266 (22.0)2726 (5.3)8540 (16.7)4289 (23.9)1123 (6.2)3166 (17.6)
Stroke, not otherwise specified28 721 (52.3)9193 (18.0)11 440 (63.6)
M edian a ge , years ( IQR ) 76.4 (65.9–83.9)78.5 (68.2–85.4)83.8 (76.6–89.3)
Sex, male 27 215 (49.5)24 308 (47.7)6893 (38.3)
Ethnic group
WhiteSouth AsianBlackOther (including Mixed)Unknown/missing50 161 (91.3)848 (1.5)584 (1.1)494 (0.9)2842 (5.2)46 993 (92.1)724 (1.4)571 (1.1)528 (1.0)2290 (4.5)15 347 (85.4)148 (0.8)131 (0.7)179 (1.0)2172 (12.1)
Family history of IHD 8064 (14.7)7054 (13.8)1774 (9.9)
Smoking status
Never smokedEx-smokerCurrent smokerMissing21 871 (39.8)23 658 (43.1)8949 (16.3)451 (0.8)20 607 (40.4)21 916 (43.0)7879 (15.4)611 (1.2)8225 (45.8)6827 (38.0)2133 (11.9)792 (4.4)
BMI
UnderweightNormalOverweightObeseMissing1261 (2.3)15 499 (28.2)16 059 (29.2)10 629 (19.4)11 481 (20.9)1275 (2.5)14 496 (28.4)14 074 (27.6)9252 (18.1)11 916 (23.4)715 (4.0)4946 (27.5)3374 (18.8)1910 (10.6)7032 (39.1)
Atrial fibrillation 8939 (16.3)9965 (19.5)4069 (22.6)
Diabetes 9317 (17.0)9063 (17.8)2986 (16.6)
H ypertension 31 578 (57.5)30 249 (59.3)10 723 (59.6)
Dyslipidaemia 11 454 (20.9)10 386 (20.4)2896 (16.1)
  • Patients might be represented in ≥1 column if their stroke(s) was recorded in ≥1 data source. Age, atrial fibrillation, diabetes, hypertension, and dyslipidaemia were determined at the time of the recorded stroke. BMI and smoking status were determined at the time of the first recorded stroke (in a given dataset) and assumed to be the same for any subsequent strokes in that patient. Family history of IHD refers to a family history of myocardial infarction and angina.

  • BMI = body mass index. CPRD = Clinical Practice Research Datalink. HES = Hospital Episode Statistics. IHD = ischaemic heart disease. IQR = interquartile range. ONS = Office for National Statistics. SAH = subarachnoid haemorrhage.

  • aIn CPRD, a total of 54 929 discrete stroke events were recorded in 49 791 individual patients. bIn HES, a total of 51 013 discrete stroke events were recorded in 47 481 individual patients. cIncludes intracerebral haemorrhagic stroke and haemorrhagic strokes not otherwise specified.