Table 2. Model discrimination in the external validation cohort for identifying familial hypercholesterolaemia in general practice (n = 1 030 183)

Models	AUC(c-statistic)	Standard error^a	95% CI
FAMCAT	0.844	0.005	0.834 to 0.854
Simon Broome criteria^b	0.730	0.006	0.719 to 0.741
Dutch Lipid Clinic Network criteria^c	0.766	0.006	0.755 to 0.778
Cholesterol >99^th centile^d	0.579	0.005	0.571 to 0.588

^aJack-knife procedure to estimate standard errors.²⁰^bTotal cholesterol >7.5 mmol/l or LDL-cholesterol >4.9 mmol/l+ family history of premature myocardial infarction.²^cScore based on LDL-cholesterol, family history, clinical history, and physical examination.⁹^dThe UK National Institute for Health and Care Excellence recommendation of screening for FH for cholesterol >99^th centile. That is, total cholesterol >9.0 mmol/l or LDL-cholesterol >6.6 mmol/l if aged >30 years; total cholesterol >7.5 mmol/l or LDL-cholesterol >4.9 mmol/l if aged ≤30 years.²