Models | AUC(c-statistic) | Standard errora | 95% CI |
---|---|---|---|
FAMCAT | 0.844 | 0.005 | 0.834 to 0.854 |
Simon Broome criteriab | 0.730 | 0.006 | 0.719 to 0.741 |
Dutch Lipid Clinic Network criteriac | 0.766 | 0.006 | 0.755 to 0.778 |
Cholesterol >99th centiled | 0.579 | 0.005 | 0.571 to 0.588 |
aJack-knife procedure to estimate standard errors.20bTotal cholesterol >7.5 mmol/l or LDL-cholesterol >4.9 mmol/l+ family history of premature myocardial infarction.2cScore based on LDL-cholesterol, family history, clinical history, and physical examination.9dThe UK National Institute for Health and Care Excellence recommendation of screening for FH for cholesterol >99th centile. That is, total cholesterol >9.0 mmol/l or LDL-cholesterol >6.6 mmol/l if aged >30 years; total cholesterol >7.5 mmol/l or LDL-cholesterol >4.9 mmol/l if aged ≤30 years.2