| MRC complex intervention stage mapping | |||
|---|---|---|---|
| WP1 | De scription | Systematic review of disease management programmes tested in HFpEF populations (see Prospero: CRD42017067980). | Identifying the evidence base. |
| Loc ation | Cambridge, UK | ||
| Recruitment | N/A | ||
| Data collection | Commenced October 2017 – completed September 2019 | ||
| WP2a | Des cription | Qualitative interview study to determine patient and health professionals’ preferences, perspectives on burden of illness and treatment, care requirements, and organisation of services and/or support in HFpEF. | Identifying and/or developing theory.Modelling process and outcomes. |
| Loc ation | Collaborative, multi-site study involving Cambridge, Keele, and Manchester (UK). Sites are utilising the NIHR Primary Care Research Network to identify general practices in their region through which recruitment of patients and primary care clinicians will be managed. Secondary and primary care-based HFS services will be approached to augment recruitment. Other healthcare providers and commissioners will be identified via local networks. | ||
| Rec ruitment | Commenced October 2017 – planned end March 2020 | ||
| Data collection | Data collection involves face-to-face or telephone interview with patients ±their carers and healthcare professionals managing or structuring care for patients with HFpEF, including but not limited to HFS nurses, cardiologists, GPs, practice nurses, healthcare commissioners, and rehabilitation specialists. | ||
| WP2b | Des cription | Prospective longitudinal observational cohort study that will identify probable HFpEF patients, confirm HFpEF status, characterise the cohort at baseline, and prospectively follow-up confirmed HFpEF cases for 1 year. | Modelling process and outcomes.Estimate recruitment and retention.Determine sample sizePreliminary testing of procedures. |
| Loc ation | Collaborative, multi-site study involving the Universities of Cambridge and Oxford, and Cardiology/Care of the Elderly services at North West Anglia and Guy’s and St. Thomas’ NHS Foundation Trust. Cambridge and Oxford will utilise the NIHR Primary Care Research Network to identify general practices in their region through which recruitment of patients will be managed. | ||
| Rec ruitment | Commenced July 2018 – planned end July 2020. | ||
| Data collection | Data collection involves a baseline visit where a diagnostic echocardiogram will be performed (previously performed diagnostic echocardiograms will be used at secondary care sites) to confirm the presence or absence of HFpEF. Additional assessments at baseline are described in Table 2. | ||
| WP2c | Des cription | Qualitative interview sub-study employing a framework analysis approach to explore hospitalisation in HFpEF patients, transitions of care, and their carers’ perspectives. | Identifying and/or developing theory.Modelling process and outcomes. |
| Loc ation | Sub-study within the Cambridge longitudinal cohort sample. | ||
| Rec ruitment | Commenced December 2018 – planned end July 2020. | ||
| Data collection | Data collection involves face-to-face interviews with patients and their carers. Basic demographic information and interview notes and/or reflections will also be collected. | ||
| WP3 | Des cription | Summary statement and questions presented to stakeholders to gauge consensus, explore disparity, identify sticking points, and elicit programme refinements. | Identifying and/or developing theory.Modelling process and outcomes.Preliminary testing of procedures.Understanding change process. |
| Location | UK-wide, diverse sample of non-collocated 'experts' with various levels and domains of expertise (including but not limited to: patients, primary care physicians, cardiologists, echocardiography specialists, HFS, and heart failure charities). | ||
| Rec ruitment | Commenced April 2019 – planned end December 2020. | ||
| Data collection | Using a structured online system, the experts will be asked to discuss the summary statement. Comments are aggregated, then quantitatively and qualitatively analysed using statistical modelling techniques to enable decision-making based on the input from the expert panellists. |
PROSPERO is the international prospective register of systematic reviews, accessible at https://www.crd.york.ac.uk/prospero/
HFpEF = heart failure with preserved ejection fraction. HFS = heart failure specialist. MRC = Medical Research Council. N/A = not applicable. NIHR = National Institute for Health Research. WP = work package.