Table 3. Probabilistic costs, health outcomes, and cost per UTI resolved per treatment regimen modelled
Total cost, £UTIs resolved, nCost per UTI resolved, £
Baseline sensitivity analysesScenarios
Trimethoprim 200 mg twice daily for 7 days608577069699173
Fosfomycin 3 g once6584278778077
Nitrofurantoin (MR) 100 mg twice daily for 7 days6984982818784100
Pivmecillinam 200 mg twice daily for 7 days6776688969899
Nitrofurantoin 50 mg four times a day for 7 days787999897104101
Pivmecillinam 200 mg three times a day for 7 days78753103103106106
Pivmecillinam 400 mg twice daily for 3 days78704111111114114
Trimethoprim 200 mg once81609133131130161
Nitrofurantoin 100 mg four times a day for 3 days87631138139147144
  • Note: treatments ordered by lowest cost per UTI resolved.

  • Baseline analysis compared with the two deterministic scenarios tested: A = resistance rates from pathogens other than E. coli; B = updated resistance measures for trimethoprim, nitrofurantoin, and pivmecillinam; and C = estimated effectiveness for 3-day dosing, which is in line with the current guidance from Public Health England for use of these treatments. MR = modified release. UTI = urinary tract infection.