| Cut-off point | Treated (N = 85) | Not treated (N = 192) | Sensitivity, % (95% CI) | Specificity, % (95% CI) | PPV, % (95% CI) | NPV, % (95% CI) | |
|---|---|---|---|---|---|---|---|
| Derivation (n = 277) | ≥1.50 | 80 | 154 | 94.1 (89.1 to 99.1) | 19.8 (14.2 to 25.4) | 34.2 (28.1 to 40.3) | 88.4 (78.8 to 98.0) |
| ≥2.25 | 73 | 94 | 85.9 (78.5 to 93.3) | 51.0 (44.0 to 58.1) | 43.7 (36.2 to 51.2) | 89.1 (83.3 to 94.9) | |
| ≥2.50 | 73 | 88 | 85.9 (78.5to 93.3) | 54.2 (47.1 to 61.2) | 45.3 (37.7 to 53.0) | 89.7 (84.1 to 95.2) | |
| ≥2.75 | 71 | 80 | 83.5 (75.6 to 91.4) | 58.3 (51.4 to 65.3) | 47.0 (39.1 to 55.0) | 88.9 (83.4 to 94.4) | |
| Cut-off point |
Treated
(N = 122) |
Not treated
(N = 111) |
Sensitivity, %
(95% CI) |
Specificity, %
(95% CI) |
PPV, %
(95% CI) |
NPV, %
(95% CI) | |
| Validation (n = 233) | ≥1.50 | 119 | 90 | 97.5 (94.8 to 100.3) | 18.9 (11.6 to 26.2) | 56.9 (50.2 to 63.7) | 87.5 (74.3 to 100.7) |
| ≥2.25 | 100 | 64 | 82.0 (75.1 to 88.8) | 42.3 (33.2 to 51.5) | 61.0 (53.5 to 68.4) | 68.1 (57.1 to 79.1) | |
| ≥2.50 | 99 | 63 | 81.1 (74.2 to 88.1) | 43.2 (34.0 to 52.5) | 61.1 (53.6 to 68.6) | 67.6 (56.7 to 78.5) | |
| ≥2.75 | 93 | 57 | 76.2 (68.7 to 83.8) | 48.6 (39.4 to 57.9) | 62.0 (54.2 to 69.8) | 65.1 (54.8 to 75.3) |