PT - JOURNAL ARTICLE AU - Rodríguez-Laso, Ángel AU - Martín-Lesende, Iñaki AU - Sinclair, Alan AU - Sourdet, Sandrine AU - Tosato, Matteo AU - Rodríguez-Mañas, Leocadio TI - Diagnostic accuracy of the FRAIL scale plus functional measures for frailty screening: a cross-sectional study AID - 10.3399/BJGPO.2021.0220 DP - 2022 Sep 01 TA - BJGP Open PG - BJGPO.2021.0220 VI - 6 IP - 3 4099 - http://bjgpopen.org/content/6/3/BJGPO.2021.0220.short 4100 - http://bjgpopen.org/content/6/3/BJGPO.2021.0220.full SO - BJGP Open2022 Sep 01; 6 AB - Background There is little knowledge of the diagnostic accuracy of screening programmes for frailty in primary care settings.Aim To assess a two-step strategy consisting of the administration of the FRAIL scale to those who are non-dependent and aged ≥75 years, followed-up by measurement of the Short Physical Performance Battery (SPPB) or gait speed in those who are positive.Design & setting Cross-sectional and longitudinal cohort study. Analysis of primary care data from the FRAILTOOLS project at five European cities.Method All primary care patients consecutively attending were enrolled. They received the index tests, plus the Fried frailty phenotype (FP) and the frailty index to assess their frailty status. Mortality and worsening of dependency in basic and instrumental activities of daily living (BADL and IADL) over 1 year were ascertained.Results Prevalence of frailty based on FP was 14.9% in the 362 participants. A FRAIL scale score ≥1 had a sensitivity of 83.3% (95% confidence interval [CI] = 73.1 to 93.6) to detect frailty. A positive result and an SPPB score <11 had a sensitivity of 72.2% (95% CI = 59.9 to 84.6); when combined with a gait speed <1.1 m/s, the sensitivity was 80.0% (95% CI = 68.5 to 91.5). Two-thirds of those screened as positive were not frail. In the best scenario, sensitivities of this last combination to detect IADL and BADL worsening were 69.4% (95% CI = 59.4 to 79.4) and 63.6% (95% CI = 53.4 to 73.9), respectively.Conclusion Combining the FRAIL scale with other functional measures offers an acceptable screening approach for frailty. Accurate prediction of worsening dependency and death need to be confirmed through the piloting of a frailty screening programme.