RT Journal Article SR Electronic T1 Identifying familial hypercholesterolaemia in primary care: Validation and optimisation of a clinical tool (FAMCAT) JF BJGP Open JO BJGP Open FD Royal College of General Practitioners SP bjgpopen20X101114 DO 10.3399/bjgpopen20X101114 A1 Akyea, Ralph Kwame A1 Qureshi, Nadeem A1 Joe, Kai A1 de Lusignan, Simon A1 Sherlock, Julian A1 McGee, Christopher A1 Weng, Stephen YR 2020 UL http://bjgpopen.org/content/early/2020/10/22/bjgpopen20X101114.abstract AB Background: Familial Hypercholesterolaemia (FH), an inherited lipid disorder causing premature heart disease, is severely underdiagnosed. Aim: To evaluated the accuracy of a clinical tool (FAMCAT) for identifying FH in primary care. Design and setting: Retrospective cohort study of 1,030,183 patients, from the UK Royal College of General Practitioners (RCGP) Research and Surveillance Centre (RSC) database, aged over 16 years. Method: The FAMCAT algorithm was compared to methods of FH detection recommended by national guidelines (Simon-Broome and Dutch Lipid Clinic Score diagnostic criteria and cholesterols levels >99th centile). Discrimination and calibration were assessed by area under the receiver operating curve (AUC) and comparing observed versus predicted cases. Results: 1,707 patients had a diagnosis of FH. FAMCAT showed high levels of discrimination (AUC 0.844, 95% CI 0.834-0.854), performing significantly better than Simon-Broome criteria (AUC 0.730, 95% CI 0.719-0.741), Dutch Lipid Clinic Score (AUC 0.766, 95% CI 0.755-0.778), and screening cholesterols >99th centile (AUC 0.579, 95% CI 0.571-0.588). Inclusion of premature myocardial infarction and fitting cholesterol as a continuous variable improved the accuracy of FAMCAT (AUC 0.894, 95% CI, 0.885-0.903). Conclusion: Better performance of the FAMCAT algorithm, compared to other approaches for case-finding of FH in primary care, has been confirmed in a separate population cohort.