RT Journal Article SR Electronic T1 Patient decision aids for antidepressant use in pregnancy: a pilot randomised controlled trial in the UK JF BJGP Open JO BJGP Open FD Royal College of General Practitioners SP bjgpopen19X101666 DO 10.3399/bjgpopen19X101666 VO 3 IS 4 A1 Khalifeh, Hind A1 Molyneaux, Emma A1 Brauer, Ruth A1 Vigod, Simone A1 Howard, Louise M YR 2019 UL http://bjgpopen.org/content/3/4/bjgpopen19X101666.abstract AB Background Decision-making regarding antidepressant use in pregnancy is challenging, given the uncertain evidence base on the benefits and risks for women and their children. Patient decision aids (PDAs) can improve shared decision-making for complex health decisions but no evidence-based PDAs exist for antidepressant use in pregnancy.Aim To assess the feasibility of a full-scale randomised controlled trial (RCT) to evaluate the efficacy of an electronic PDA on antidepressant use in pregnancy.Design & setting A UK-based pilot parallel-group RCT.Method The study recruited women whose clinicians recommended an antidepressant for depression in a current or planned pregnancy, and who were uncertain about antidepressant use while pregnant. Women were recruited via clinician or self-referral, and randomised to online access to the PDA or online access to standard resource list, with primary follow-up at 4 weeks and longer-term follow-up. The primary outcome was protocol feasibility (recruitment target of 50 women and follow-up rate of 80%). Outcome measures for a future full-scale RCT included the decisional conflict scale (DCS).Results Fifty-one women were recruited with a follow-up rate of 90.2% at 4 weeks. The PDA received good overall satisfaction ratings (mean 4.2/5). Analysis of covariance (ANCOVA) indicated a small improvement in decisional conflict at 4 weeks, accounting for baseline scores (DCS regression coefficient = -3.5, 95% confidence intervals [CI = -12.6 to 5.6]).Conclusion This pilot RCT for an electronic PDA on antidepressant use in pregnancy showed that the study protocol was feasible, with high rates of participant satisfaction among those randomised to the PDA.