Article Figures & Data
Figures
- Figure 1. Flowchart illustrating formation of the patient cohort. Patients were included in the cohort on fulfilling all inclusion criteria: aged ≥18 years, residing in Denmark for at least 5 consecutive years, listed with a Danish general practice clinic included in the study, diagnosed with atrial fibrillation, CHA2DS2-VASc score≥2, and no history of undergoing a left atrial appendage closure procedure. During the study period, patients entered the cohort once all inclusion criteria were met. The last criterion fulfilled is depicted in the flowchart. Patients were followed until they reached one of the following endpoints: undergoing a left atrial appendage closure procedure, no longer being listed with a Danish general practice clinic included in the study, death, emigration, or the end of the study period, whichever came first. The white boxes indicate patients entering the cohort, and the grey boxes indicate patients leaving the cohort
- Figure 2. Flowchart illustrating the selection of participating general practice clinics. Based on a cohort of all adult Danish residents (Supplementary Table S2), all clinics with at least one patient listed in 2021 were identified. From the same cohort, the cumulative number of patient years, as well as the number of listed patients at the beginning and end of the study period were determined. Clinics with a cumulative number of patient years of ≤500 in 2021 or with ≤500 listed patients on 1 January or 31 December 2021 were excluded
- Figure 3. Variation in oral anticoagulant propensity between general practice clinics. Observed to expected ratios for adherence to oral anticoagulant treatment in general practice based on the actual patient population of the clinic (blue curve) and a reference population (red curve). Clinics were reported in groups of five on the plot to preserve anonymity
- Figure 4. Association between general practice clinic characteristics and OAC propensity. Coef = coefficient. OAC = oral anticoagulant treatment
Tables
General practice clinics, n (%) AF patient years in 2021, years (%) Total 1666 (100%) Total 146 993 (100%) Size List size <1500 patients 552 (33.1) 23 606 (16.1) 1500–3499 patients 688 (41.3) 54 329 (37.0) ≥3500 426 (25.6) 69 058 (47.0) Patient population Average age Low 556 (33.4) 29 491 (20.1) Average 555 (33.3) 56 389 (38.4) High 555 (33.3) 61 112 (41.6) Disease burden Low 556 (33.4) 30 685 (20.9) Average 555 (33.3) 55 585 (37.8) High 555 (33.3) 60 723 (41.3) Deprivation Affluent (index score <30) 513 (30.8) 44 390 (30.2) Average (index score 30–39) 709 (42.6) 69 487 (47.3) Deprived (index score ≥40) 444 (26.7) 33 116 (22.5) Setting City size <10 000 citizens 500 (30.0) 57 675 (39.2) 10 000–99 999 citizens 538 (32.3) 52 272 (35.6) ≥100 000 citizens 628 (37.7) 37 045 (25.2) Region North Denmark Region 154 (9.2) 16 049 (10.9) Central Denmark Region 343 (20.6) 31 973 (21.8) Region of Southern Denmark 344 (20.7) 34 049 (23.2) Capital Region of Denmark 595 (35.7) 40 077 (27.3) Region Zealand 230 (13.8) 24 846 (16.9) AF = atrial fibrillation.
Observed variation (p90/p10) Random variation (p90/p10) Excess variation (observed/random) 1.08/0.90 = 1.20 1.07/0.92 = 1.16 1.20/1.16 = 1.03 p10 = 10th percentile. p90 = 90th percentile
Supplementary Data
- Lau_10.3399BJGPO.2024.0197_supp.docx -
Supplementary material is not copyedited or typeset, and is published as supplied by the author(s). The author(s) retain(s) responsibility for its accuracy.
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General practice-related variation in oral anticoagulant treatment of atrial fibrillation: a nationwide cohort study
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