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Research

Re-examining advice to complete antibiotic courses: a qualitative study with clinicians and patients

Aleksandra J Borek, George Edwards, Marta Santillo, Marta Wanat, Margaret Glogowska, Christopher C Butler, Ann Sarah Walker, Gail Hayward and Sarah Tonkin-Crine
BJGP Open 2023; 7 (2): BJGPO.2022.0170. DOI: https://doi.org/10.3399/BJGPO.2022.0170
Aleksandra J Borek
1 Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK
2 National Institute for Health and Care Research (NIHR) Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance, University of Oxford, Oxford, UK
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  • ORCID record for Aleksandra J Borek
  • For correspondence: aleksandra.borek@phc.ox.ac.uk
George Edwards
1 Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK
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Marta Santillo
1 Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK
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Marta Wanat
1 Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK
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Margaret Glogowska
1 Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK
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Christopher C Butler
1 Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK
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Ann Sarah Walker
2 National Institute for Health and Care Research (NIHR) Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance, University of Oxford, Oxford, UK
3 Nuffield Department of Medicine, University of Oxford, Oxford, UK
4 NIHR Oxford Biomedical Research Centre, Oxford, UK
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Gail Hayward
1 Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK
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Sarah Tonkin-Crine
1 Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK
2 National Institute for Health and Care Research (NIHR) Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance, University of Oxford, Oxford, UK
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Article Figures & Data

Tables

    • View popup
    Table 1. Sample characteristics
    Characteristicsna
    Clinicians (n = 11)
    Interview length, minutes, range (mean)29–55 (43)
    Professional role
     GP7
     Advanced nurse practitioner2
     Clinical pharmacist1
     Physician associate1
    Years in the current role, range (median)2.5–40 (6)
    Years of clinical experience, range (median)8.5–47 (16)
    Sex
     Female7
     Male4
    Patients (n = 19)
    Focus group length, minutes77
    Interview length, minutes, range (mean)25–51 (39)
    Sex
     Female18
     Male1
    Age, years, range (median)21–81 (43)
    Self-reported experience of UTIsb
     Females with recurrent and/or chronic UTIs (currently or at some point in life)14
     Females with 1–3 uncomplicated UTIs in the past year (without history of recurrent and/or chronic UTIs)4
     Male who experienced one UTI1
    • aUnless otherwise stated. bSupplementary Boxes S1 and S2 contain a brief summary of each patient's experience of UTIs. UTIs = urinary tract infections.

    • View popup
    Table 2. Main arguments about SAWB advice
    ThemesReasons to be amenable to the SAWB adviceReasons to be concerned or sceptical about the SAWB advice
    Change in evidence, guidelines, and education required for SAWB
    • Medicine evolves (antibiotic courses are not always evidence based and have shortened), so open to SAWB if evidence and guidelines change (C)

    • Antibiotic courses seem arbitrary — clinicians prescribe different courses and many patients do not take full courses anyway (C)

    • SAWB is unfamiliar and at odds with the ingrained advice to complete antibiotic courses (C and P)

    Current approach to antibiotics influences attitudes to SAWB
    • SAWB seen as more appropriate and beneficial with longer antibiotic courses for UTIs or other infections (C and P), especially as it is already given with longer courses (C)

    • SAWB advice already given or used in recurrent UTIs (C and P)

    • 3-day antibiotics for UTIs are already short so SAWB would be less or not relevant for UTIs (C and P)

    • SAWB with short courses for UTIs would have little impact or benefit so it is not a priority (C)

    • Patients with experience of recurrent and/or complicated UTIs perceived current courses as already too short so were against stopping even earlier (P)

    Balancing risks and benefits of SAWB is needed
    • Would consider SAWB if evidence shows it is safe and beneficial (C and P)

    • SAWB may help reduce antibiotic side effects (C and P) and antimicrobial resistance (C)

    • SAWB may be more suitable for other infections than UTIs where risks of recurrence and/or complications are lower (P)

    • SAWB may lead to recurrence, complications, and antimicrobial resistance (C and P)

    • Participants with recurrent and/or chronic UTIs were particularly concerned about SAWB causing resistant UTIs (P)

    Importance of effective communication and personalisation of SAWB
    • SAWB may help empower patients as part of shared decision making (C and P)

    • SAWB advice more acceptable from a trusted clinician and when personalised (P)

    • Unsure how SAWB should be best formulated and that it may be unclear to patients when to stop antibiotics (C and P)

    • Unsure and concerned about what happens with unused or leftover antibiotics (C and P)

    • SAWB inappropriate for those perceived to be unable to make treatment decisions (C and P)

    • C = views expressed by clinicians. P = views expressed by patients. SAWB = stopping antibiotics when better. UTI = urinary tract infection.

Supplementary Data

  • Borek_BJGPO.2022.0170_Supp.pdf -

    Supplementary material is not copyedited or typeset, and is published as supplied by the author(s). The author(s) retain(s) responsibility for its accuracy.

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Re-examining advice to complete antibiotic courses: a qualitative study with clinicians and patients
Aleksandra J Borek, George Edwards, Marta Santillo, Marta Wanat, Margaret Glogowska, Christopher C Butler, Ann Sarah Walker, Gail Hayward, Sarah Tonkin-Crine
BJGP Open 2023; 7 (2): BJGPO.2022.0170. DOI: 10.3399/BJGPO.2022.0170

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Re-examining advice to complete antibiotic courses: a qualitative study with clinicians and patients
Aleksandra J Borek, George Edwards, Marta Santillo, Marta Wanat, Margaret Glogowska, Christopher C Butler, Ann Sarah Walker, Gail Hayward, Sarah Tonkin-Crine
BJGP Open 2023; 7 (2): BJGPO.2022.0170. DOI: 10.3399/BJGPO.2022.0170
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Keywords

  • antibiotic course
  • drug resistance, microbial
  • Antimicrobial stewardship
  • communicable diseases
  • Primary health care
  • Qualitative research

More in this TOC Section

  • Podcasting in primary care: attitudes of Scottish GP specialty trainees and trainers towards podcast-based education in primary care
  • Patient perceptions of relational continuity in England: insights from two cross-sectional surveys
  • COVID-19 and patient-reported experience of general practice in England
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