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Protocol

Symptom patterns and life with post-acute COVID-19 in children aged 8–17 years: a mixed-methods study protocol

Alice Faux-Nightingale, Claire Burton, Helen Twohig, Milica Blagojevic-Bucknall, Will Carroll, Carolyn A Chew-Graham, Kate Dunn, Francis Gilchrist, Toby Helliwell, Oliver Lawton, Sarah Lawton, Christian Mallen, Benjamin Saunders, Danielle van der Windt and Victoria Welsh
BJGP Open 2023; 7 (2): BJGPO.2022.0149. DOI: https://doi.org/10.3399/BJGPO.2022.0149
Alice Faux-Nightingale
1 School of Medicine, Keele University, Keele, Newcastle, UK
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  • ORCID record for Alice Faux-Nightingale
  • For correspondence: a.faux-nightingale{at}keele.ac.uk
Claire Burton
1 School of Medicine, Keele University, Keele, Newcastle, UK
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Helen Twohig
1 School of Medicine, Keele University, Keele, Newcastle, UK
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Milica Blagojevic-Bucknall
1 School of Medicine, Keele University, Keele, Newcastle, UK
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Will Carroll
1 School of Medicine, Keele University, Keele, Newcastle, UK
2 Staffordshire Children's Hospital at Royal Stoke, Stoke-on-Trent, United Kingdom
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Carolyn A Chew-Graham
1 School of Medicine, Keele University, Keele, Newcastle, UK
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Kate Dunn
1 School of Medicine, Keele University, Keele, Newcastle, UK
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Francis Gilchrist
1 School of Medicine, Keele University, Keele, Newcastle, UK
2 Staffordshire Children's Hospital at Royal Stoke, Stoke-on-Trent, United Kingdom
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Toby Helliwell
1 School of Medicine, Keele University, Keele, Newcastle, UK
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Oliver Lawton
1 School of Medicine, Keele University, Keele, Newcastle, UK
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Sarah Lawton
1 School of Medicine, Keele University, Keele, Newcastle, UK
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Christian Mallen
1 School of Medicine, Keele University, Keele, Newcastle, UK
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Benjamin Saunders
1 School of Medicine, Keele University, Keele, Newcastle, UK
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Danielle van der Windt
1 School of Medicine, Keele University, Keele, Newcastle, UK
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Victoria Welsh
1 School of Medicine, Keele University, Keele, Newcastle, UK
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    Figure 1. SPLaT-19 study flowchart. CRN = Clinical Research Network. CTU = clinical trials unit. CYP = children and young people. PIS = participant information sheet.

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    Table 1. Data collection schedule (questionnaires)
    DescriptionMeasureBaseline3 months6 months9 months12 months
    Primary outcome measure
    Health-related quality of lifeKIDSCREEN-10 Index (10 items, 0–5 scale)✓✓✓✓✓
    Secondary outcomes measures
    SymptomsLong-COVID-19 symptom inventory (ISARIC/NICE)✓✓✓✓✓
    Health and social care use✓✓✓✓✓
    New diagnoses✓✓✓✓✓
    School absence and attainment✓✓✓✓✓
    Baseline measures
    Age✓
    Sex✓
    Ethnic group✓
    Postcode✓
    Height✓
    Weight✓
    Living status✓
    Vaccination status (if applicable)✓✓✓✓✓
    If had COVID-19: type of acute symptoms; symptom duration; symptom severity; place of care (home, ward, ICU)a ✓✓✓✓✓
    Pre-existing health conditions and prescribed medicationInventory or medication list✓
    Pre-existing mental health needsInventory or service use✓
    Exposure to long-COVID in adultsHave any adults in your household had ‘long-COVID’? Yes, no, don’t know✓
    Physical activity✓
    • aIf participant reports new case of COVID-19 over the course of the study, this question will be asked again.

    • ICU = intensive care unit. ISARIC = International Severe Acute Respiratory and emerging Infection Consortium. NICE = National Institute for Health and Care Excellence.

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Symptom patterns and life with post-acute COVID-19 in children aged 8–17 years: a mixed-methods study protocol
Alice Faux-Nightingale, Claire Burton, Helen Twohig, Milica Blagojevic-Bucknall, Will Carroll, Carolyn A Chew-Graham, Kate Dunn, Francis Gilchrist, Toby Helliwell, Oliver Lawton, Sarah Lawton, Christian Mallen, Benjamin Saunders, Danielle van der Windt, Victoria Welsh
BJGP Open 2023; 7 (2): BJGPO.2022.0149. DOI: 10.3399/BJGPO.2022.0149

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Symptom patterns and life with post-acute COVID-19 in children aged 8–17 years: a mixed-methods study protocol
Alice Faux-Nightingale, Claire Burton, Helen Twohig, Milica Blagojevic-Bucknall, Will Carroll, Carolyn A Chew-Graham, Kate Dunn, Francis Gilchrist, Toby Helliwell, Oliver Lawton, Sarah Lawton, Christian Mallen, Benjamin Saunders, Danielle van der Windt, Victoria Welsh
BJGP Open 2023; 7 (2): BJGPO.2022.0149. DOI: 10.3399/BJGPO.2022.0149
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Keywords

  • COVID-19
  • child health
  • primary health care
  • long-COVID
  • symptom patterns

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