Article Figures & Data
Figures
- Figure 1. Conceptual framework describing the relationships between home-built environment intervention, systemic inflammatory response, clinical outcomes and general practice care of survivors of cancer.
*In daytime. Minimum melanopic equivalent daylight illuminance at the eye measured in the vertical plane at 1.2m height. 25(OH)D = 25 hydroxyvitamin D. 5-HT = 5-hydroxytryptamine/serotonin. AC = adrenal cortex. ALB = albumin. COR = cortisol. COX = cyclooxygenase. CRP = c-reactive protein. E = environmental. EDI = melanopic equivalent daylight illuminance. ESR = erythrocyte sedimentation rate. Fer = ferritin. FGN = fibrinogen. G-CSF = granulocyte-colony stimulating factor. GP = general practice. Hb = haemoglobin. H-BE = home-built environment. HDL-C = high-density lipoprotein cholesterol. IGF = insulin-like growth factor. IL = interleukin. LC = leukocyte count. LED = light-emitting diode. MEL = melatonin. NSAIDs = non-steroidal anti-inflammatory drugs. Personal E exposure = Personal environmental exposure. PG = prostaglandin. PLT = platelets. PV = plasma viscosity. RBC = red blood cells. SIR = systemic inflammatory response. TC = total cholesterol. TG = triglycerides. TP = total protein. TX = therapy. VEGF = vascular endothelial growth factor. WBC = white blood cells.
Tables
Group ID Marker ID Marker Circulating individual inflammatory markersa G1–10 Inflammatory mediators G1 Cytokines 1–42 Interleukins 94–96 Interferons 43–47 Colony-stimulating factors 97–99 Tumour necrosis factor 48–51 Adipokines 100 Macrophage migration inhibitory factor 52–93 Chemokines G2 Growth factors 101 Transforming growth factor 112 Hepatocyte growth factor 102–104 Vascular endothelial growth factor 113 Nerve growth factor 105 Platelet-derived growth factor 114,115 Insulin, insulin-like growth factor 106–108 Fibroblast growth factor 116–118 Endothelins 109,110 Epidermal growth factor 119,120 Renin-angiotensin system 111 Placental growth factor 121–129 Angiopoietin, angiopoietin-like protein G3 Transcription factors 130 Nuclear factor kappa B 133–138 Signal transducers and activators of transcription 131,132 Nuclear factor erythroid 2-related factor 139–141 Hypoxia-inducible factor G4 Immunoglobulins 142–149 Cell-adhesion molecules 150–152 Programmed cell death protein G5 Eicosanoids 153,154 Cyclooxygenase 160 Lipoxygenase 155–158 Prostaglandins 161–164 Leukotrienes 159 Thromboxane 165 Lipoxins G6 Acute phase proteins 166–168 C-reactive protein 188–195 Plasminogen activation system 169–172 Pentraxins family 196–197 Microglobulins 173–175 Serum amyloid A 198–201 Transport proteins 176–178 Alpha globulins 202–205 Complement system 179–184 Extracellular matrix proteins 206–209 Albumin, transferrin 185–187 Fibrinogen, D-dimer G7 Matrix metalloproteinases 210–225 Matrix metalloproteinases G8 Redox active mediators 226,227 Metalloproteins (haemoglobin; heme) 233 Calcitriol 228–231 Vitamin D (25-hydroxyvitamin D) 234 Melatonin 232 Calcidiol 235 6-sulfatoxymelatonin G9 Lipoproteins 236–238 Very low-, low-, high-density lipoprotein 241 Total cholesterol 239 Oxidised low-density lipoprotein 242 Triglycerides 240 Apolipoprotein G10 Adrenal cortex hormones and neurotransmitters 243–245 Glucocorticoids 251–253 Catecholamines 246–250 Neurotransmitters G11–13 Inflammatory effector cells 254 Platelets 259–265 White blood cells 255–258 Red blood cells Combining multiple inflammatory markers (into a score)a cG11.13 White blood cells-platelets parameters 266 Lymphocyte to monocyte ratio 269 Derived Neutrophil to lymphocyte ratio 267 Neutrophil to lymphocyte ratio 270–272 Novel combined scoring systemb 268 Platelet to lymphocyte ratio cG6 Acute phase proteins parameters, combinations 273–275 Glasgow prognostic scores 277–280 Novel combined scoring systemb 276 Prognostic inflammatory and nutritional index cG11.6 White blood cells-acute phase proteins parameters, combinations 281–285 Novel combined scoring systemb cG11.6.8 White blood cells-acute phase proteins-redox active mediators parameters 286 Combined haemoglobin, albumin, lymphocyte, platelet cG10 Lipoprotein particle-derived measure of insulin resistance 287 Lipoprotein insulin resistance score aThe proposed panel of 287 cancer-associated inflammatory biomarkers could be modified and upgraded over time in accordance with clinical efficacy tested and promising clinical results of novel candidates. Before eligibility, it was verified that each biomarker could be identified in blood, urine, or saliva samples.bNovel combined inflammation-based scoring systems proposed in further research will be incorporated into panel.
G = group. cG = combined group. ID = identifier
Supplementary Data
- HG_BJGPO.2022.0104_Supp.pdf -
Supplementary material is not copyedited or typeset, and is published as supplied by the author(s). The author(s) retain(s) responsibility for its accuracy.
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