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Research

Quality-adjusted life years for digital cognitive behavioural therapy for insomnia (Sleepio): a secondary analysis

Elizabeth A Stokes, Richard Stott, Alasdair L Henry, Colin A Espie and Christopher B Miller
BJGP Open 2022; 6 (4): BJGPO.2022.0090. DOI: https://doi.org/10.3399/BJGPO.2022.0090
Elizabeth A Stokes
1 Health Economics Research Centre, Nuffield Department of Population Health, University of Oxford, Oxford, UK
2 National Institute for Health and Care Research Oxford Biomedical Research Centre, Oxford, UK
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Richard Stott
3 Department of Psychiatry, University of Oxford, Oxford, UK
4 Big Health Inc., CA, US and London, UK
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Alasdair L Henry
4 Big Health Inc., CA, US and London, UK
5 Sir Jules Thorn Sleep & Circadian Neuroscience Institute, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK
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Colin A Espie
4 Big Health Inc., CA, US and London, UK
5 Sir Jules Thorn Sleep & Circadian Neuroscience Institute, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK
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Christopher B Miller
4 Big Health Inc., CA, US and London, UK
5 Sir Jules Thorn Sleep & Circadian Neuroscience Institute, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK
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  • ORCID record for Christopher B Miller
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Article Figures & Data

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    Table 1. EQ-5D scores and QALYs to 24 weeks, with multiple imputation used to handle missing values
    OutcomedCBT (n = 853), mean (SE)Control (n = 858), mean (SE)Mean difference (95% CI)
    EQ-5D
    Week 00.772 (0.004)0.772 (0.004)–0.0001(–0.012 to 0.012)
    Week 40.799 (0.005)0.785 (0.005)0.014(–0.001 to 0.028)
    Week 80.826 (0.005)0.787 (0.005)0.039(0.024 to 0.053)a
    Week 240.820 (0.005)0.787 (0.005)0.033(0.018 to 0.048)a
    QALYs
    0–24 weeks0.375 (0.002)0.362 (0.002)0.014(0.008 to 0.019)a
    • a P<0.05. dCBT = digital cognitive behavioural therapy. QALYs = quality-adjusted life years. SE = standard error.

    • View popup
    Table 2. EQ-5D scores and QALYs from 24 weeks to 48 weeks, with multiple imputation used to handle missing values
    OutcomedCBT (n = 853), mean (SE)Control (n = 858), mean (SE)Mean difference (95% CI)
    EQ-5D
    Week 240.820 (0.005)0.787 (0.005)0.033(0.018 to 0.048)a
    Week 360.810 (0.006)0.787 (0.005)0.023(0.010 to 0.037)a
    Week 480.817 (0.006)0.787 (0.005)0.030(0.016 to 0.043)a
    QALYs
    24–48 weeks0.375 (0.002)0.362 (0.002)0.013(0.007 to 0.018)a
    • a P<0.05. dCBT = digital cognitive behavioural therapy. QALYs = quality-adjusted life years. SE = standard error.

    • View popup
    Table 3. Quality-adjusted life years from baseline to 48 weeks
    QALYsdCBT (n = 853), mean (SE)Control (n = 858), mean (SE)Mean difference (95% CI)
    0 to 24 weeks0.375 (0.002)0.362 (0.002)0.014(0.008 to 0.019)a
    24 to 48 weeks0.375 (0.002)0.362 (0.002)0.013(0.007 to 0.018)a
    0 to 48 weeks0.750 (0.004)0.724 (0.003)0.026(0.016 to 0.036)a
    • a P<0.05. dCBT = digital cognitive behavioural therapy. QALYs = quality-adjusted life years. SE = standard error.

Supplementary Data

  • Miller_BJGPO.2022.0090_supp.pdf -

    Supplementary material is not copyedited or typeset, and is published as supplied by the author(s). The author(s) retain(s) responsibility for its accuracy.

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Quality-adjusted life years for digital cognitive behavioural therapy for insomnia (Sleepio): a secondary analysis
Elizabeth A Stokes, Richard Stott, Alasdair L Henry, Colin A Espie, Christopher B Miller
BJGP Open 2022; 6 (4): BJGPO.2022.0090. DOI: 10.3399/BJGPO.2022.0090

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Quality-adjusted life years for digital cognitive behavioural therapy for insomnia (Sleepio): a secondary analysis
Elizabeth A Stokes, Richard Stott, Alasdair L Henry, Colin A Espie, Christopher B Miller
BJGP Open 2022; 6 (4): BJGPO.2022.0090. DOI: 10.3399/BJGPO.2022.0090
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Keywords

  • Insomnia; cognitive behavioural therapy
  • quality of life
  • quality-adjusted life years
  • sleep
  • health care economics and organisations

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