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Research

Effectiveness of professional and patient-oriented strategies in reducing vitamin D and B12 test ordering in primary care: a cluster randomised intervention study

Saskia van Vugt, Evelien de Schepper, Sanne van Delft, Nicolaas Zuithoff, Niek de Wit and Patrick Bindels
BJGP Open 2021; 5 (6): BJGPO.2021.0113. DOI: https://doi.org/10.3399/BJGPO.2021.0113
Saskia van Vugt
1 Department of General Practice, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
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  • ORCID record for Saskia van Vugt
  • For correspondence: saskiavvugt{at}gmail.com
Evelien de Schepper
2 Department of General Practice, Erasmus Medical Center, Rotterdam, The Netherlands
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Sanne van Delft
3 Saltro, Diagnostic Center for Primary Care, Utrecht, The Netherlands
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Nicolaas Zuithoff
1 Department of General Practice, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
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Niek de Wit
1 Department of General Practice, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
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Patrick Bindels
2 Department of General Practice, Erasmus Medical Center, Rotterdam, The Netherlands
2 Department of General Practice, Erasmus Medical Center, Rotterdam, The Netherlands
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    Figure 1. Flow diagram of the study and its participating health centres
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    Figure 2. Number of ordered vitamin tests in pre-intervention period (in quartiles) related to reduction in number of ordered tests during intervention period. pts = patients.

Tables

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    Table 1. Baseline characteristics of participating GPs, including pre-intervention numbers of vitamin testing
    CharacteristicTotalIntervention group
    Strategy 1(GP only)Strategy 2(GP and patient)P value
    Health centres, n 261313 
    GPs,n 15878800.85
    Male, n (%)47 (30)25 (32)22 (28)0.72
    Population, n 195 39497 65897 7360.99
    SES, mean (range)a 0.26(−2.58–2.06)0.53(−2.40–2.06)0.21(−2.58–1.66)0.48
    Vitamin D tests pre-intervention, n 17 52710 27772500.30
    Vitamin D/1000 patients pre-intervention, n (range)88
    (12–262)
    102
    (32–262)
    75(12–150)0.22
    Vitamin B12 tests pre-intervention, n 12 304724250620.36
    Vitamin B12/1000 patients pre-intervention, n (range)59
    (7–198)b
    69
    (7–198)
    49
    (15–156)
    0.21
    GPs who followed e-learning, n (%) 76 (48)28 (36)48 (60)0.11
    GPs present at first training session, n (%) 50 (32)26 (33)24 (30)0.86
    GPs present at second training session, n (%) 50 (32)24 (31)26 (33)0.85
    • aSES data, linked by four digital postal codes to location of health centre.17 bMean difference Utrecht-Rotterdam = –60 (95% CI = –94 to –26), P = 0.06. SES = socioeconomic status.

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    Table 2. Reduction in number of vitamin D and B12 tests
    CharacteristicTotalDe-implementation strategy
    Strategy 1 (GP only)Strategy 2 (GP and patient)
    Health centres, n 261313
    Vitamin D    
    Reduction, % (range)23(−9–70)19(−4–70)29(−9–28)
    Absolute reduction in vitamin D/1000 patients, mean (range)22 (−6–98)24 (−6–98)21 (−6–51)
    Vitamin B12    
    Reduction, % (range)20(−19–63)18(−3–63)22(−19–42)
    Absolute reduction in vitamin B12/1000 patients, mean (range)12 (−6–69)15 (−3–69)9 (−6–63)
    • View popup
    Table 3. Results of ordered vitamin D and B12 tests
    Vitamin DVitamin B12
    Pre-intervention yearIntervention yearPre-intervention yearIntervention year
    Average value (range)56 nmol/L (5–327)55 nmol/L (10–309)304 pmol/L(34–1476)304 pmol/L(36–1476)
    Female patients, %72727272
    Age, years, mean (SD)48 (20)47 (20)51 (21)50 (20)
    Reference value: %<50 nmol/L if >70 years: 30<30 nmol/L if <70 years: 17<50 nmol/L if >70 years: 32<30 nmol/L if <70 years: 18<148 pmol/l: 17<148 pmol/L: 16
    • SD = standard deviation.

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Effectiveness of professional and patient-oriented strategies in reducing vitamin D and B12 test ordering in primary care: a cluster randomised intervention study
Saskia van Vugt, Evelien de Schepper, Sanne van Delft, Nicolaas Zuithoff, Niek de Wit, Patrick Bindels
BJGP Open 2021; 5 (6): BJGPO.2021.0113. DOI: 10.3399/BJGPO.2021.0113

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Effectiveness of professional and patient-oriented strategies in reducing vitamin D and B12 test ordering in primary care: a cluster randomised intervention study
Saskia van Vugt, Evelien de Schepper, Sanne van Delft, Nicolaas Zuithoff, Niek de Wit, Patrick Bindels
BJGP Open 2021; 5 (6): BJGPO.2021.0113. DOI: 10.3399/BJGPO.2021.0113
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Keywords

  • overdiagnosis
  • Primary Care
  • vitamins
  • diagnostic tests, routine
  • Netherlands
  • vitamin B12
  • vitamin D

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  • Rising scabies incidence and the growing burden on GPs: a retrospective longitudinal study
  • Patient characteristics associated with clinically coded long COVID: an OpenSAFELY study using electronic health records
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