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Research

Lipid levels and major adverse cardiovascular events in patients initiated on statins for primary prevention: an international population-based cohort study protocol

Joseph E Blais, Ralph Kwame Akyea, Annelize Coetzee, Amy HY Chan, Wallis CY Lau, Kenneth KC Man, Jeff Harrison, Esther W Chan, Kebede A Beyene, Ian CK Wong and Stephen Weng
BJGP Open 2021; 5 (1): bjgpopen20X101127. DOI: https://doi.org/10.3399/bjgpopen20X101127
Joseph E Blais
1 Centre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China
BScPharm
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  • ORCID record for Joseph E Blais
  • For correspondence: jblais{at}connect.hku.hk
Ralph Kwame Akyea
2 Primary Care Stratified Medicine, Division of Primary Care, University of Nottingham, Nottingham, UK
MB ChB, MPH
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  • ORCID record for Ralph Kwame Akyea
Annelize Coetzee
3 School of Pharmacy, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
MPharm
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Amy HY Chan
3 School of Pharmacy, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
PhD
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Wallis CY Lau
1 Centre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China
4 Research Department of Practice and Policy, University College London School of Pharmacy, London, UK
PhD
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Kenneth KC Man
1 Centre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China
4 Research Department of Practice and Policy, University College London School of Pharmacy, London, UK
PhD
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Jeff Harrison
3 School of Pharmacy, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
PhD
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Esther W Chan
1 Centre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China
PhD
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Kebede A Beyene
3 School of Pharmacy, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
PhD
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Ian CK Wong
1 Centre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China
4 Research Department of Practice and Policy, University College London School of Pharmacy, London, UK
PhD
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Stephen Weng
2 Primary Care Stratified Medicine, Division of Primary Care, University of Nottingham, Nottingham, UK
PhD
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    Figure 1. Cohort study restricted to new users of statins for primary prevention of cardiovascular disease. Figure adapted from www.repeatinitiative.org. 25 aDefined as total cholesterol, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol. bFor example, body mass index, blood pressure, and deprivation index. cCensored at earliest of MACE, death, disenrollment, or end of the study period. CVD = cardiovascular disease. LDL-C = low-density lipoprotein cholesterol. MACE = major adverse cardiovascular event. non-HDL-C = non–high-density lipoprotein cholesterol. Rx = prescription.

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    Supplementary material is not copyedited or typeset, and is published as supplied by the author(s). The author(s) retain(s) responsibility for its accuracy.

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Lipid levels and major adverse cardiovascular events in patients initiated on statins for primary prevention: an international population-based cohort study protocol
Joseph E Blais, Ralph Kwame Akyea, Annelize Coetzee, Amy HY Chan, Wallis CY Lau, Kenneth KC Man, Jeff Harrison, Esther W Chan, Kebede A Beyene, Ian CK Wong, Stephen Weng
BJGP Open 2021; 5 (1): bjgpopen20X101127. DOI: 10.3399/bjgpopen20X101127

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Lipid levels and major adverse cardiovascular events in patients initiated on statins for primary prevention: an international population-based cohort study protocol
Joseph E Blais, Ralph Kwame Akyea, Annelize Coetzee, Amy HY Chan, Wallis CY Lau, Kenneth KC Man, Jeff Harrison, Esther W Chan, Kebede A Beyene, Ian CK Wong, Stephen Weng
BJGP Open 2021; 5 (1): bjgpopen20X101127. DOI: 10.3399/bjgpopen20X101127
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Keywords

  • hydroxymethylglutaryl-CoA reductase inhibitors
  • cholesterol
  • major adverse cardiovascular events
  • primary prevention
  • cohort studies

More in this TOC Section

  • Perceptions and practices of UK GPs towards youth vaping: a questionnaire-based study
  • Exploring the barriers and facilitators to discussing social media in primary care for young adults with mental health concerns: a qualitative study
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