Sustained proton pump inhibitor deprescribing among dyspeptic patients in general practice: a return to self-management through a programme of education and alginate rescue therapy. A prospective interventional study

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Figure 1. Study protocol summary
DTREP = Dyspepsia Therapy Review and Education Programme. PPI = proton pump inhibitor.
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Figure 2. DTREP impact on PPI use across regional PCOs in England, Scotland, and Wales
The proportion of PPI-treated patients and change in PPI status are summarised for each study PCO.
DNA = did not attend. DTREP = Dyspepsia Therapy Review and Education Programme. NLA = no longer active. PCO = primary care organisation (clinical commissioning group). PPI = proton pump inhibitor.
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Figure 3. Net impact of DTREP programme on prescriptions
DTREP = Dyspepsia Therapy Review and Education Programme. PPI = proton pump inhibitor.

Table 1. Net impact of DTREP programme on proton pump inhibitor status

Outcome	Patients, n (%)
Total eligible	6249 (100)
Step down Step down then off Step off only	2173 (34.8)312 (5.0)2206 (35.3)
Total successful reduction	4691 (75.1)
Did not attend Unsuccessful, reverted Under review and/or refused No longer active	520 (8.3)541 (8.7)163 (2.6)334 (5.3)
Total reduction	1558 (24.9)