Corticotropin-releasing hormone (CRH) plays a central role in the regulation of the
hypothalamic-pituitary-adrenal (HPA)-axis, ie, the final common pathway in the stress response. The …

OBJECTIVE—To review the effects of monotherapy with α-glucosidase inhibitors (AGIs) for
patients with type 2 diabetes, with respect to mortality, morbidity, glycemic control, insulin …

Aims Previous systematic reviews have found that drug‐related morbidity accounts for 4.3%
of preventable hospital admissions. None, however, has identified the drugs most commonly …

Renewed discussion about whether or not adult neurogenesis exists in the human
hippocampus, and the nature and strength of the supporting evidence, has been reignited by two …

Adult hippocampal neurogenesis, a once unorthodox concept, has changed into one of the
most rapidly growing fields in neuroscience. The present report results from the ECNP …

Background It is expected that GPs are increasingly confronted with a large group of patients
with symptoms persisting three weeks after initial symptoms of a mild (managed in the …

Environmental challenges are part of daily life for any individual. In fact, stress appears to be
increasingly present in our modern, and demanding, industrialized society. Virtually every …

Even though in vivo imaging studies document significant reductions of hippocampal
volume in depressed patients, the exact underlying cellular mechanisms are unclear. Since …

… A modification of the method of Lucassen et al. (30) was used for the in situ hybridization …
Hybridization conditions were the same as those described by Lucassen et al. (30), except for …

Glia are essential for brain functioning during development and in the adult brain. Here, we
discuss the various roles of both microglia and astrocytes, and their interactions during brain …