User profiles for J. Richardson

Jane S. Richardson

- Verified email at duke.edu - Cited by 82898

Julie E. Richards

- Verified email at kp.org - Cited by 3435

[HTML][HTML] MolProbity: all-atom structure validation for macromolecular crystallography

…, LW Murray, JS Richardson, DC Richardson - … Section D: Biological …, 2010 - scripts.iucr.org
MolProbity is a structure-validation web service that provides broad-spectrum solidly based
evaluation of model quality at both the global and local levels for both proteins and nucleic …

[HTML][HTML] Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix

…, RJ Read, JS Richardson, DC Richardson… - … Section D: Structural …, 2019 - scripts.iucr.org
Diffraction (X-ray, neutron and electron) and electron cryo-microscopy are powerful
methods to determine three-dimensional macromolecular structures, which are required to …

The anatomy and taxonomy of protein structure

JS Richardson - Advances in protein chemistry, 1981 - Elsevier
Publisher Summary This chapter investigates the anatomy and taxonomy of protein structures.
A protein is a polypeptide chain made up of amino acid residues linked together in a …

Identification of miRNA changes in Alzheimer's disease brain and CSF yields putative biomarkers and insights into disease pathways

…, C Chen, RK Prinjha, JC Richardson… - Journal of …, 2008 - content.iospress.com
MicroRNAs have essential functional roles in brain development and neuronal specification
but their roles in neurodegenerative diseases such as Alzheimer’s disease (AD) is unknown…

MolProbity: all-atom contacts and structure validation for proteins and nucleic acids

…, JS Richardson, DC Richardson - Nucleic acids …, 2007 - academic.oup.com
MolProbity is a general-purpose web server offering quality validation for 3D structures of
proteins, nucleic acids and complexes. It provides detailed all-atom contact analysis of any …

[HTML][HTML] PHENIX: a comprehensive Python-based system for macromolecular structure solution

…, RJ Read, DC Richardson, JS Richardson… - … Section D: Biological …, 2010 - scripts.iucr.org
Macromolecular X-ray crystallography is routinely applied to understand biological processes
at a molecular level. However, significant time and effort are still required to solve and …

Structure validation by Cα geometry: ϕ, ψ and Cβ deviation

…, JS Richardson, DC Richardson - Proteins: Structure …, 2003 - Wiley Online Library
Geometrical validation around the C is described, with a new C measure and updated
Ramachandran plot. Deviation of the observed C atom from ideal position provides a single …

Gene ontology: tool for the unification of biology

…, A Kasarskis, S Lewis, JC Matese, JE Richardson… - Nature …, 2000 - nature.com
Genomic sequencing has made it clear that a large fraction of the genes specifying the core
biological functions are shared by all eukaryotes. Knowledge of the biological role of such …

[HTML][HTML] Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior

…, RM Chemelli, H Tanaka, SC Williams, JA Richardson… - Cell, 1998 - cell.com
The hypothalamus plays a central role in the integrated control of feeding and energy
homeostasis. We have identified two novel neuropeptides, both derived from the same precursor …

[HTML][HTML] A calcineurin-dependent transcriptional pathway for cardiac hypertrophy

…, CL Antos, B Markham, J Richardson, J Robbins… - Cell, 1998 - cell.com
In response to numerous pathologic stimuli, the myocardium undergoes a hypertrophic
response characterized by increased myocardial cell size and activation of fetal cardiac genes. …