[HTML][HTML] MolProbity: all-atom structure validation for macromolecular crystallography
…, LW Murray, JS Richardson, DC Richardson - … Section D: Biological …, 2010 - scripts.iucr.org
MolProbity is a structure-validation web service that provides broad-spectrum solidly based
evaluation of model quality at both the global and local levels for both proteins and nucleic …
evaluation of model quality at both the global and local levels for both proteins and nucleic …
[HTML][HTML] Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix
Diffraction (X-ray, neutron and electron) and electron cryo-microscopy are powerful
methods to determine three-dimensional macromolecular structures, which are required to …
methods to determine three-dimensional macromolecular structures, which are required to …
The anatomy and taxonomy of protein structure
JS Richardson - Advances in protein chemistry, 1981 - Elsevier
Publisher Summary This chapter investigates the anatomy and taxonomy of protein structures.
A protein is a polypeptide chain made up of amino acid residues linked together in a …
A protein is a polypeptide chain made up of amino acid residues linked together in a …
Identification of miRNA changes in Alzheimer's disease brain and CSF yields putative biomarkers and insights into disease pathways
…, C Chen, RK Prinjha, JC Richardson… - Journal of …, 2008 - content.iospress.com
MicroRNAs have essential functional roles in brain development and neuronal specification
but their roles in neurodegenerative diseases such as Alzheimer’s disease (AD) is unknown…
but their roles in neurodegenerative diseases such as Alzheimer’s disease (AD) is unknown…
MolProbity: all-atom contacts and structure validation for proteins and nucleic acids
…, JS Richardson, DC Richardson - Nucleic acids …, 2007 - academic.oup.com
MolProbity is a general-purpose web server offering quality validation for 3D structures of
proteins, nucleic acids and complexes. It provides detailed all-atom contact analysis of any …
proteins, nucleic acids and complexes. It provides detailed all-atom contact analysis of any …
[HTML][HTML] PHENIX: a comprehensive Python-based system for macromolecular structure solution
Macromolecular X-ray crystallography is routinely applied to understand biological processes
at a molecular level. However, significant time and effort are still required to solve and …
at a molecular level. However, significant time and effort are still required to solve and …
Structure validation by Cα geometry: ϕ, ψ and Cβ deviation
…, JS Richardson, DC Richardson - Proteins: Structure …, 2003 - Wiley Online Library
Geometrical validation around the C is described, with a new C measure and updated
Ramachandran plot. Deviation of the observed C atom from ideal position provides a single …
Ramachandran plot. Deviation of the observed C atom from ideal position provides a single …
Gene ontology: tool for the unification of biology
Genomic sequencing has made it clear that a large fraction of the genes specifying the core
biological functions are shared by all eukaryotes. Knowledge of the biological role of such …
biological functions are shared by all eukaryotes. Knowledge of the biological role of such …
[HTML][HTML] Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior
…, RM Chemelli, H Tanaka, SC Williams, JA Richardson… - Cell, 1998 - cell.com
The hypothalamus plays a central role in the integrated control of feeding and energy
homeostasis. We have identified two novel neuropeptides, both derived from the same precursor …
homeostasis. We have identified two novel neuropeptides, both derived from the same precursor …
[HTML][HTML] A calcineurin-dependent transcriptional pathway for cardiac hypertrophy
…, CL Antos, B Markham, J Richardson, J Robbins… - Cell, 1998 - cell.com
In response to numerous pathologic stimuli, the myocardium undergoes a hypertrophic
response characterized by increased myocardial cell size and activation of fetal cardiac genes. …
response characterized by increased myocardial cell size and activation of fetal cardiac genes. …