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Single dose fosfomycin trometamol versus multiple dose norfloxacin over three days for uncomplicated UTI in general practice

Einzeldosis Fosfomycin Trometamol im Vergleich zu Mehrfachdosen Norfloxacin für drei Tage zur Therapie der unkomplizierten Harnwegsinfektion in der Allgemeinpraxis

  • Discussion 2 Fosfomycin Trometamol International Clinical Studies
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Summary

The aim of this study was to carry out a small-scale bacteriological comparison between a standard therapy with norfloxacin 400 mg twice daily, and fosfomycin trometamol (3 g) in single dose in uncomplicated urinary tract infections (UTI) in women. Only patients with UTI with cultures showing a bacterial count of 105 or more bacteria/ml were included in the study (n=32; ages 16–75 years). After one week sterile cultures were obtained in 14 of 16 cases in the fosfomycin trometamol group, and in 14 of 16 cases in the norfloxacin group. After one month eradication was confirmed in 13 of 16 patients in the fosfomycin trometamol group, and in nine of 16 patients in the norfloxacin group. Recurrence was seen in one case in the fosfomycin trometamol group, and in five cases in the norfloxacin group. The reinfection and persistence rates were identical (1/16) in both groups. The main clinical symptoms disappeared very rapidly after initiating treatment, and the correlation with the bacteriological data after one week was excellent. Both drugs were well tolerated and the compliance for fosfomycin trometamol was 100%.

Zusammenfassung

Die Standardtherapie Norfloxacin, 400 mg zweimal täglich, sollte in einer bakteriologisch überwachten Studie an einer kleinen Fallzahl mit einer Einzeldosis von 3 g Fosfomycin Trometamol in der Therapie der unkomplizierten Harnwegsinfektion (HWI) bei Frauen verglichen werden. In die Studie wurden nur Patientinnen aufgenommen, bei denen eine HWI mit positiver Urinkultur mit 105 KBE/ml oder darüber festgestellt wurde (n=32; Alter 16–75 Jahre). Eine Woche nach Therapie waren die Urinkulturen bei je 14 der 16 Patientinnen der beiden Therapiegruppen steril. Nach einem Monat hatten in der Fosfomycin Trometamol-Gruppe weiterhin 13 und in der Norfloxacin-Gruppe neun der 16 Patientinnen eine negative Urinkultur. Rezidive traten in einem Fall unter Fosfomycin Trometamol und in fünf Fällen unter Norfloxacin auf. In beiden Gruppen kam es je einmal zu einer Reinfektion und Erregerpersistenz. Nach Therapiebeginn verschwanden die klinischen Symptome sehr rasch, was gut mit den bakteriologischen Daten nach einer Woche übereinstimmte. Beide Medikamente wurden gut vertragen, die Compliance in der Fosfomycin Trometamol-Gruppe betrug 100%.

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Reynaert, J., Van Eyck, D. & Vandepitte, J. Single dose fosfomycin trometamol versus multiple dose norfloxacin over three days for uncomplicated UTI in general practice. Infection 18 (Suppl 2), S77–S79 (1990). https://doi.org/10.1007/BF01643432

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